Literature DB >> 32069075

Notch1-Nrf2 signaling crosstalk provides myocardial protection by reducing ROS formation.

Xue-Liang Zhou1, Xia Wu1, Rong-Rong Zhu2, Hua Xu1, Yun-Yun Li1, Qi-Rong Xu1, Sheng Liu1, Song-Qing Lai1, Xinping Xu1, Li Wan1, Qi-Cai Wu1, Ji-Chun Liu1.   

Abstract

Both the Notch1 and Keap1-Nrf2 signaling pathways have cardioprotective effects, but the role of Notch1-Nrf2 crosstalk in myocardial ischemia-reperfusion injury is unclear. In this study, we established hypoxia-reoxygenation in neonate rat myocardial cells and employed γ-secretase inhibitor and curcumin to inhibit and activate the Notch1 and Keap1-Nrf2 signaling pathways, respectively. We found that the combined action of the Notch1 and Keap1-Nrf2 signaling pathways significantly increased cardiomyocyte viability, inhibited cardiomyocyte apoptosis, reduced the formation of reactive oxygen species, and increased antioxidant activities. In conclusion, these findings suggest that Notch1-Nrf2 crosstalk exerts myocardial protection by reducing the formation of reactive oxygen species.

Entities:  

Keywords:  DRO; Keap1; Notch1 signaling; Nrf2; ROS; myocardial protection; protection du myocarde; signalisation Notch1

Mesh：

Substances：

Year:  2020        PMID： 32069075     DOI： 10.1139/bcb-2018-0398

Source DB:  PubMed          Journal:  Biochem Cell Biol        ISSN： 0829-8211            Impact factor:   3.626


  9 in total

1.  Protective Effects of Emodin on Oxidized Fish Oil-Induced Metabolic Disorder and Oxidative Stress through Notch-Nrf2 Crosstalk in the Liver of Teleost Megalobrama amblycephala.

Authors:  Changyou Song; Bo Liu; Hongxia Li; Yongkai Tang; Xianping Ge; Bo Liu; Pao Xu
Journal:  Antioxidants (Basel)       Date:  2022-06-15

2.  Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma.

Authors:  Kang An; Yuehan Zhang; Yingjiao Liu; Shengxi Yan; Zhaowei Hou; Meng Cao; Guangkuo Liu; Congcong Dong; Juncha Gao; Gaifang Liu
Journal:  Oncol Rep       Date:  2020-07-07       Impact factor: 3.906

3.  Keap-NRF2 signaling contributes to the Notch1 protected heart against ischemic reperfusion injury via regulating mitochondrial ROS generation and bioenergetics.

Authors:  Hua Xu; Xiao-Dan Wan; Rong-Rong Zhu; Jin-Long Liu; Ji-Chun Liu; Xue-Liang Zhou
Journal:  Int J Biol Sci       Date:  2022-02-07       Impact factor: 6.580

4.  MicroRNA-34a Promotes Ischemia-Induced Cardiomyocytes Apoptosis through Targeting Notch1.

Authors:  Jialin Pan; Lili Zhou; Cong Lin; Weihao Xue; Peng Chen; Jiafeng Lin
Journal:  Evid Based Complement Alternat Med       Date:  2022-02-28       Impact factor: 2.629

5.  DAPT suppresses proliferation and migration of hepatocellular carcinoma by regulating the extracellular matrix and inhibiting the Hes1/PTEN/AKT/mTOR signaling pathway.

Authors:  Kaijie Qiu; Chenyang Ma; Lingchao Lu; Jie Wang; Baiwen Chen; Haixiang Mao; Yanmin Wang; Haibiao Wang
Journal:  J Gastrointest Oncol       Date:  2021-06

Review 6.  Nrf2 for cardiac protection: pharmacological options against oxidative stress.

Authors:  Qin M Chen
Journal:  Trends Pharmacol Sci       Date:  2021-07-28       Impact factor: 17.638

7.  Activation of the M3AChR and Notch1/HSF1 Signaling Pathway by Choline Alleviates Angiotensin II-Induced Cardiomyocyte Apoptosis.

Authors:  Man Xu; Xue-Yuan Bi; Xiao-Rong Xue; Xing-Zhu Lu; Qiong-Ge Li; Qiang Jian; Jian-Yong Sun
Journal:  Oxid Med Cell Longev       Date:  2021-08-30       Impact factor: 6.543

Review 8.  Notch Signaling and Cross-Talk in Hypoxia: A Candidate Pathway for High-Altitude Adaptation.

Authors:  Katie A O'Brien; Andrew J Murray; Tatum S Simonson
Journal:  Life (Basel)       Date:  2022-03-16

9.  Lingonberry Improves Hepatic Lipid Metabolism by Targeting Notch1 Signaling.

Authors:  Susara Madduma Hewage; Kathy K W Au-Yeung; Suvira Prashar; Charith U B Wijerathne; Karmin O; Yaw L Siow
Journal:  Antioxidants (Basel)       Date:  2022-02-27
  9 in total

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