OBJECTIVE: To examine the preliminary effectiveness of a modular, transdiagnostic, behavioral/cognitive-behavioral intervention (MATCH) compared with standard manualized treatments (SMT) and usual care (UC) for treating youth with severe irritability. METHOD: We analyzed data from an effectiveness trial in which treatment-referred youths (N = 174; Mage = 10.6 years; 70% boys) were randomized to receive MATCH, SMT, or UC (ns = 53-62). Masked assessments of irritability, diagnoses, impairment, and internalizing, externalizing, total, and top problems were collected from caregivers and youths at pre- and posttreatment, weekly during treatment, and quarterly through 2-year follow-up. Baseline measures of irritability and impairment were used to identify a subsample characterized by severe irritability and mood dysregulation (SIMD; n = 81; Mage = 10.2 years; 69% boys; ns = 24-31 across conditions). Longitudinal multilevel models and ANOVAs were estimated to examine numerous clinical outcomes within and between conditions. RESULTS: Among youth with SIMD, MATCH produced faster improvements than UC and SMT, with medium or large effect sizes in two thirds of all comparisons tested (Mdn ES = 0.60). Although SIMD youths in all conditions showed reductions in DSM diagnoses, only MATCH predicted significantly fewer posttreatment diagnoses than UC (averaging 1.0 fewer; ES = 0.93). Finally, among the entire sample, MATCH and SMT equivalently outperformed UC in reducing irritability (ES = 0.49) and the effects of each treatment condition on other outcomes were not moderated by baseline irritability. CONCLUSIONS: Extant behavioral/cognitive-behavioral psychotherapies-already well-established and widely used-may be helpful for treating youths with severe irritability. A transdiagnostic, modular format showed the most consistently favorable pattern of results across multiple outcomes, informants, and measurement schedules. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
RCT Entities:
OBJECTIVE: To examine the preliminary effectiveness of a modular, transdiagnostic, behavioral/cognitive-behavioral intervention (MATCH) compared with standard manualized treatments (SMT) and usual care (UC) for treating youth with severe irritability. METHOD: We analyzed data from an effectiveness trial in which treatment-referred youths (N = 174; Mage = 10.6 years; 70% boys) were randomized to receive MATCH, SMT, or UC (ns = 53-62). Masked assessments of irritability, diagnoses, impairment, and internalizing, externalizing, total, and top problems were collected from caregivers and youths at pre- and posttreatment, weekly during treatment, and quarterly through 2-year follow-up. Baseline measures of irritability and impairment were used to identify a subsample characterized by severe irritability and mood dysregulation (SIMD; n = 81; Mage = 10.2 years; 69% boys; ns = 24-31 across conditions). Longitudinal multilevel models and ANOVAs were estimated to examine numerous clinical outcomes within and between conditions. RESULTS: Among youth with SIMD, MATCH produced faster improvements than UC and SMT, with medium or large effect sizes in two thirds of all comparisons tested (Mdn ES = 0.60). Although SIMD youths in all conditions showed reductions in DSM diagnoses, only MATCH predicted significantly fewer posttreatment diagnoses than UC (averaging 1.0 fewer; ES = 0.93). Finally, among the entire sample, MATCH and SMT equivalently outperformed UC in reducing irritability (ES = 0.49) and the effects of each treatment condition on other outcomes were not moderated by baseline irritability. CONCLUSIONS: Extant behavioral/cognitive-behavioral psychotherapies-already well-established and widely used-may be helpful for treating youths with severe irritability. A transdiagnostic, modular format showed the most consistently favorable pattern of results across multiple outcomes, informants, and measurement schedules. (PsycINFO Database Record (c) 2020 APA, all rights reserved).
Authors: Reut Naim; Katharina Kircanski; Andrea Gold; Ramaris E German; Mollie Davis; Samantha Perlstein; Michal Clayton; Olga Revzina; Melissa A Brotman Journal: BMJ Open Date: 2021-03-10 Impact factor: 2.692
Authors: Spencer C Evans; Michael C Roberts; Jared W Keeley; Tahilia J Rebello; Francisco de la Peña; John E Lochman; Jeffrey D Burke; Paula J Fite; Lourdes Ezpeleta; Walter Matthys; Eric A Youngstrom; Chihiro Matsumoto; Howard F Andrews; María Elena Medina-Mora; José L Ayuso-Mateos; Brigitte Khoury; Mayya Kulygina; Rebeca Robles; Pratap Sharan; Min Zhao; Geoffrey M Reed Journal: J Child Psychol Psychiatry Date: 2020-05-12 Impact factor: 8.982
Authors: Simone P Haller; Joel Stoddard; Christian Botz-Zapp; Michal Clayton; Caroline MacGillivray; Gretchen Perhamus; Kelsey Stiles; Katharina Kircanski; Ian S Penton-Voak; Yair Bar-Haim; Marcus Munafò; Kenneth E Towbin; Melissa A Brotman Journal: J Am Acad Child Adolesc Psychiatry Date: 2021-06-17 Impact factor: 8.829