Literature DB >> 32067644

Role of the Left Atrial Appendage in Systemic Homeostasis, Arrhythmogenesis, and Beyond.

Ghulam Murtaza1, Bharath Yarlagadda2, Krishna Akella1, Domenico G Della Rocca3, Rakesh Gopinathannair1, Andrea Natale3, Dhanunjaya Lakkireddy4.   

Abstract

The left atrial appendage (LAA) affects body homeostasis via atrial natriuretic peptide and the renin-angiotensin-aldosterone system and plays an important role in atrial compliance. Approximately 90% of clots in nonvalvular atrial fibrillation (AF) are formed in the LAA. AF is the most common sustained cardiac arrhythmia and is frequently associated with stroke. Because anticoagulation for stroke prophylaxis carries a higher bleeding risk, LAA closure via epicardial and endocardial approaches has gained popularity and is being increasingly pursued for arrhythmogenic, homeostatic, and stroke-reduction benefits. This review discusses the homeostatic role of the LAA and its involvement in arrhythmogenesis and thrombus formation.
Copyright © 2019 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  Arrhythmogenesis; Left atrial appendage; Systemic homeostasis

Mesh：

Year:  2020        PMID： 32067644     DOI： 10.1016/j.ccep.2019.11.004

Source DB:  PubMed          Journal:  Card Electrophysiol Clin        ISSN： 1877-9182


  4 in total

1.  Depolarization of the Rat Atria in Experimental Simulation of the Holiday Heart Syndrome.

Authors:  S L Smirnova; I M Roshchevskaya; V N Stolyaruk; M B Vititnova; I B Tsorin; S A Kryzhanovsky
Journal:  Dokl Biochem Biophys       Date:  2020-12-25       Impact factor: 0.788

2.  Simultaneous appendage ligation and atrial ablation - is it worth the risk?

Authors:  Jalaj Garg; Dhanunjaya Lakkireddy
Journal:  Indian Pacing Electrophysiol J       Date:  2021 Mar-Apr

Review 3.  Catheter Ablation of Life-Threatening Ventricular Arrhythmias in Athletes.

Authors:  Nicola Tarantino; Domenico G Della Rocca; Nicole S De Leon De La Cruz; Eric D Manheimer; Michele Magnocavallo; Carlo Lavalle; Carola Gianni; Sanghamitra Mohanty; Chintan Trivedi; Amin Al-Ahmad; Rodney P Horton; Mohamed Bassiouny; J David Burkhardt; G Joseph Gallinghouse; Giovanni B Forleo; Luigi Di Biase; Andrea Natale
Journal:  Medicina (Kaunas)       Date:  2021-02-26       Impact factor: 2.430

4.  Left Atrial Appendage Depth and Tachycardia Bradycardia Syndrome as Important Predictors of Left Atrial Appendage Thrombus in Patients with Nonvalvular Atrial Fibrillation.

Authors:  Yinge He; Panpan Chen; Ziqiang Zhu; Junhua Sun; Yujie Zhao
Journal:  Comput Math Methods Med       Date:  2022-03-30       Impact factor: 2.238
  4 in total

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