Literature DB >> 32067068

In vitro prediction of organ toxicity: the challenges of scaling and secondary mechanisms of toxicity.

Jan G Hengstler1, Anna-Karin Sjögren2, Daniele Zink3, Jorrit J Hornberg4.   

Abstract

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Year:  2020        PMID： 32067068     DOI： 10.1007/s00204-020-02669-7

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


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  32 in total

1.  Bottom-up physiologically-based biokinetic modelling as an alternative to animal testing.

Authors:  James C Y Chan; Shawn P F Tan; Zee Upton; Eric C Y Chan
Journal:  ALTEX       Date:  2019-05-10       Impact factor: 6.043

Review 2.  Competency of different cell models to predict human hepatotoxic drugs.

Authors:  M José Gómez-Lechón; Laia Tolosa; Isabel Conde; M Teresa Donato
Journal:  Expert Opin Drug Metab Toxicol       Date:  2014-10-09       Impact factor: 4.481

3.  Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.

Authors:  Wiebke Albrecht; Franziska Kappenberg; Tim Brecklinghaus; Iain Gardner; Jörg Rahnenführer; Jan G Hengstler; Regina Stoeber; Rosemarie Marchan; Mian Zhang; Kristina Ebbert; Hendrik Kirschner; Marianna Grinberg; Marcel Leist; Wolfgang Moritz; Cristina Cadenas; Ahmed Ghallab; Jörg Reinders; Nachiket Vartak; Christoph van Thriel; Klaus Golka; Laia Tolosa; José V Castell; Georg Damm; Daniel Seehofer; Alfonso Lampen; Albert Braeuning; Thorsten Buhrke; Anne-Cathrin Behr; Axel Oberemm; Xiaolong Gu; Naim Kittana; Bob van de Water; Reinhard Kreiling; Susann Fayyaz; Leon van Aerts; Bård Smedsrød; Heidrun Ellinger-Ziegelbauer; Thomas Steger-Hartmann; Ursula Gundert-Remy; Anja Zeigerer; Anett Ullrich; Dieter Runge; Serene M L Lee; Tobias S Schiergens; Lars Kuepfer; Alejandro Aguayo-Orozco; Agapios Sachinidis; Karolina Edlund
Journal:  Arch Toxicol       Date:  2019-06-27       Impact factor: 5.153

4.  Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition.

Authors:  Dipayan Chaudhuri; Daniel J Artiga; Sunday A Abiria; David E Clapham
Journal:  Proc Natl Acad Sci U S A       Date:  2016-03-14       Impact factor: 11.205

5.  Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases.

Authors:  Ahmed Ghallab; Géraldine Cellière; Sebastian G Henkel; Dominik Driesch; Stefan Hoehme; Ute Hofmann; Sebastian Zellmer; Patricio Godoy; Agapios Sachinidis; Meinolf Blaszkewicz; Raymond Reif; Rosemarie Marchan; Lars Kuepfer; Dieter Häussinger; Dirk Drasdo; Rolf Gebhardt; Jan G Hengstler
Journal:  J Hepatol       Date:  2015-11-27       Impact factor: 25.083

6.  A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro.

Authors:  Melanie Adler; Susanne Ramm; Marc Hafner; Jeremy L Muhlich; Esther Maria Gottwald; Elijah Weber; Alenka Jaklic; Amrendra Kumar Ajay; Daniel Svoboda; Scott Auerbach; Edward J Kelly; Jonathan Himmelfarb; Vishal S Vaidya
Journal:  J Am Soc Nephrol       Date:  2015-08-10       Impact factor: 10.121

Review 7.  Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.

Authors:  Patricio Godoy; Nicola J Hewitt; Ute Albrecht; Melvin E Andersen; Nariman Ansari; Sudin Bhattacharya; Johannes Georg Bode; Jennifer Bolleyn; Christoph Borner; Jan Böttger; Albert Braeuning; Robert A Budinsky; Britta Burkhardt; Neil R Cameron; Giovanni Camussi; Chong-Su Cho; Yun-Jaie Choi; J Craig Rowlands; Uta Dahmen; Georg Damm; Olaf Dirsch; María Teresa Donato; Jian Dong; Steven Dooley; Dirk Drasdo; Rowena Eakins; Karine Sá Ferreira; Valentina Fonsato; Joanna Fraczek; Rolf Gebhardt; Andrew Gibson; Matthias Glanemann; Chris E P Goldring; María José Gómez-Lechón; Geny M M Groothuis; Lena Gustavsson; Christelle Guyot; David Hallifax; Seddik Hammad; Adam Hayward; Dieter Häussinger; Claus Hellerbrand; Philip Hewitt; Stefan Hoehme; Hermann-Georg Holzhütter; J Brian Houston; Jens Hrach; Kiyomi Ito; Hartmut Jaeschke; Verena Keitel; Jens M Kelm; B Kevin Park; Claus Kordes; Gerd A Kullak-Ublick; Edward L LeCluyse; Peng Lu; Jennifer Luebke-Wheeler; Anna Lutz; Daniel J Maltman; Madlen Matz-Soja; Patrick McMullen; Irmgard Merfort; Simon Messner; Christoph Meyer; Jessica Mwinyi; Dean J Naisbitt; Andreas K Nussler; Peter Olinga; Francesco Pampaloni; Jingbo Pi; Linda Pluta; Stefan A Przyborski; Anup Ramachandran; Vera Rogiers; Cliff Rowe; Celine Schelcher; Kathrin Schmich; Michael Schwarz; Bijay Singh; Ernst H K Stelzer; Bruno Stieger; Regina Stöber; Yuichi Sugiyama; Ciro Tetta; Wolfgang E Thasler; Tamara Vanhaecke; Mathieu Vinken; Thomas S Weiss; Agata Widera; Courtney G Woods; Jinghai James Xu; Kathy M Yarborough; Jan G Hengstler
Journal:  Arch Toxicol       Date:  2013-08-23       Impact factor: 5.153

8.  Gene networks and transcription factor motifs defining the differentiation of stem cells into hepatocyte-like cells.

Authors:  Patricio Godoy; Wolfgang Schmidt-Heck; Karthick Natarajan; Baltasar Lucendo-Villarin; Dagmara Szkolnicka; Annika Asplund; Petter Björquist; Agata Widera; Regina Stöber; Gisela Campos; Seddik Hammad; Agapios Sachinidis; Umesh Chaudhari; Georg Damm; Thomas S Weiss; Andreas Nüssler; Jane Synnergren; Karolina Edlund; Barbara Küppers-Munther; David C Hay; Jan G Hengstler
Journal:  J Hepatol       Date:  2015-05-25       Impact factor: 25.083

9.  Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology.

Authors:  Caroline R Archer; Rebecca Sargeant; Jayati Basak; James Pilling; Jennifer R Barnes; Amy Pointon
Journal:  Sci Rep       Date:  2018-07-05       Impact factor: 4.379

10.  Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.

Authors:  Patricio Godoy; Agata Widera; Wolfgang Schmidt-Heck; Gisela Campos; Christoph Meyer; Cristina Cadenas; Raymond Reif; Regina Stöber; Seddik Hammad; Larissa Pütter; Kathrin Gianmoena; Rosemarie Marchan; Ahmed Ghallab; Karolina Edlund; Andreas Nüssler; Wolfgang E Thasler; Georg Damm; Daniel Seehofer; Thomas S Weiss; Olaf Dirsch; Uta Dahmen; Rolf Gebhardt; Umesh Chaudhari; Kesavan Meganathan; Agapios Sachinidis; Jens Kelm; Ute Hofmann; René P Zahedi; Reinhard Guthke; Nils Blüthgen; Steven Dooley; Jan G Hengstler
Journal:  Arch Toxicol       Date:  2016-06-23       Impact factor: 5.153
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  6 in total

1.  Mechanism-driven modeling of chemical hepatotoxicity using structural alerts and an in vitro screening assay.

Authors:  Xuelian Jia; Xia Wen; Daniel P Russo; Lauren M Aleksunes; Hao Zhu
Journal:  J Hazard Mater       Date:  2022-05-20       Impact factor: 14.224

2.  The rapid development of computational toxicology.

Authors:  Hermann M Bolt; Jan G Hengstler
Journal:  Arch Toxicol       Date:  2020-05-07       Impact factor: 5.153

3.  Characterization of drug-induced human mitochondrial ADP/ATP carrier inhibition.

Authors:  Stephany Jaiquel Baron; Martin S King; Edmund R S Kunji; Tom J J Schirris
Journal:  Theranostics       Date:  2021-03-05       Impact factor: 11.556

4.  Continous, non-invasive monitoring of oxygen consumption in a parallelized microfluidic in vitro system provides novel insight into the response to nutrients and drugs of primary human hepatocytes.

Authors:  Marius Busche; Dominik Rabl; Jan Fischer; Christian Schmees; Torsten Mayr; Rolf Gebhardt; Martin Stelzle
Journal:  EXCLI J       Date:  2022-01-07       Impact factor: 4.068

5.  Classification of Developmental Toxicants in a Human iPSC Transcriptomics-Based Test.

Authors:  Anna Cherianidou; Florian Seidel; Franziska Kappenberg; Nadine Dreser; Jonathan Blum; Tanja Waldmann; Nils Blüthgen; Johannes Meisig; Katrin Madjar; Margit Henry; Tamara Rotshteyn; Rosemarie Marchan; Karolina Edlund; Marcel Leist; Jörg Rahnenführer; Agapios Sachinidis; Jan G Hengstler
Journal:  Chem Res Toxicol       Date:  2022-04-13       Impact factor: 3.973

Review 6.  Endocrine-Disrupting Effects of Bisphenol A on the Cardiovascular System: A Review.

Authors:  Maria Inês Fonseca; Margarida Lorigo; Elisa Cairrao
Journal:  J Xenobiot       Date:  2022-07-13
  6 in total

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