Mihai Puia-Dumitrescu1,2, Noelle Younge2, Daniel K Benjamin3, Katie Lawson4, Cordelia Hume4, Kennedy Hill4, Jonathan Mengistu4, Aryeona Wilson4, Kanecia O Zimmerman2,4, Kaashif Ahmad5, Rachel G Greenberg6,7. 1. Department of Pediatrics, University of Washington, Seattle, WA, USA. 2. Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. 3. Department of Economics, Clemson University, Clemson, SC, USA. 4. Duke Clinical Research Institute, Durham, NC, USA. 5. MEDNAX Center for Research, Education, Quality and Safety, San Antonio, TX, USA. 6. Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. rachel.greenberg@duke.edu. 7. Duke Clinical Research Institute, Durham, NC, USA. rachel.greenberg@duke.edu.
Abstract
OBJECTIVE: To evaluate the most commonly used medications and in-hospital morbidities and mortality in infants born 22-24 weeks of gestation. STUDY DESIGN: Multicenter retrospective cohort study of infants born 22-24 weeks of gestation (2006-2016), without major congenital anomalies and with available medication data obtained from neonatal intensive care units managed by the Pediatrix Medical Group. RESULTS: This study included 7578 infants from 195 sites. Median (25th, 75th percentile): birthweight was 610 g (540, 680); the number of distinct medications used was 13 (8, 18); and different antimicrobial exposure was 4 (2, 5). The most common morbidities were BPD (41%) and grade III or IV IVH (20%), and overall survival varied from 46% (2006) to 57% (2016). CONCLUSIONS: A large number of medications were used in periviable infants. There was a high prevalence of in-hospital morbidities, and survival of this population increased over the study period.
OBJECTIVE: To evaluate the most commonly used medications and in-hospital morbidities and mortality in infants born 22-24 weeks of gestation. STUDY DESIGN: Multicenter retrospective cohort study of infants born 22-24 weeks of gestation (2006-2016), without major congenital anomalies and with available medication data obtained from neonatal intensive care units managed by the Pediatrix Medical Group. RESULTS: This study included 7578 infants from 195 sites. Median (25th, 75th percentile): birthweight was 610 g (540, 680); the number of distinct medications used was 13 (8, 18); and different antimicrobial exposure was 4 (2, 5). The most common morbidities were BPD (41%) and grade III or IV IVH (20%), and overall survival varied from 46% (2006) to 57% (2016). CONCLUSIONS: A large number of medications were used in periviable infants. There was a high prevalence of in-hospital morbidities, and survival of this population increased over the study period.
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Authors: Sandra E Juul; Thomas R Wood; Bryan A Comstock; Krystle Perez; Semsa Gogcu; Mihai Puia-Dumitrescu; Sara Berkelhamer; Patrick J Heagerty Journal: JAMA Netw Open Date: 2022-02-01
Authors: Mihai Puia-Dumitrescu; Thomas R Wood; Bryan A Comstock; Janessa B Law; Kendell German; Krystle M Perez; Semsa Gogcu; Dennis E Mayock; Patrick J Heagerty; Sandra E Juul Journal: JAMA Netw Open Date: 2022-03-01
Authors: Mihai Puia-Dumitrescu; Bryan A Comstock; Sijia Li; Patrick J Heagerty; Krystle M Perez; Janessa B Law; Thomas R Wood; Semsa Gogcu; Dennis E Mayock; Sandra E Juul Journal: JAMA Netw Open Date: 2021-07-01