| Literature DB >> 32064741 |
Melissa A Munn-Chernoff1, Emma C Johnson2, Yi-Ling Chou2, Jonathan R I Coleman3,4, Laura M Thornton1, Raymond K Walters5,6, Zeynep Yilmaz1,7, Jessica H Baker1, Christopher Hübel3,4,8, Scott Gordon9, Sarah E Medland9, Hunna J Watson1,10,11, Héléna A Gaspar3,4, Julien Bryois8, Anke Hinney12, Virpi M Leppä8, Manuel Mattheisen13,14,15,16, Stephan Ripke5,6,17, Shuyang Yao8, Paola Giusti-Rodríguez7, Ken B Hanscombe18, Roger A H Adan19,20,21, Lars Alfredsson22, Tetsuya Ando23, Ole A Andreassen24, Wade H Berrettini25, Ilka Boehm26, Claudette Boni27, Vesna Boraska Perica28,29, Katharina Buehren30, Roland Burghardt31, Matteo Cassina32, Sven Cichon33,34,35, Maurizio Clementi32, Roger D Cone36, Philippe Courtet37, Scott Crow38, James J Crowley7,14, Unna N Danner39, Oliver S P Davis40,41, Martina de Zwaan42, George Dedoussis43, Daniela Degortes44, Janiece E DeSocio45, Danielle M Dick46,47,48, Dimitris Dikeos49, Christian Dina50, Monika Dmitrzak-Weglarz51, Elisa Docampo52,53,54, Laramie E Duncan55, Karin Egberts56, Stefan Ehrlich26, Geòrgia Escaramís52,53,54, Tõnu Esko57,58, Xavier Estivill52,53,54,59, Anne Farmer3, Angela Favaro44, Fernando Fernández-Aranda60,61, Manfred M Fichter62,63, Krista Fischer57, Manuel Föcker64, Lenka Foretova65, Andreas J Forstner34,66,67,68, Monica Forzan32, Christopher S Franklin28, Steven Gallinger69, Ina Giegling70, Johanna Giuranna12, Fragiskos Gonidakis71, Philip Gorwood72,73, Monica Gratacos Mayora52,53,54, Sébastien Guillaume37, Yiran Guo74, Hakon Hakonarson74,75, Konstantinos Hatzikotoulas28,76, Joanna Hauser77, Johannes Hebebrand12, Sietske G Helder3,78, Stefan Herms33,34, Beate Herpertz-Dahlmann30, Wolfgang Herzog79, Laura M Huckins28,80, James I Hudson81, Hartmut Imgart82, Hidetoshi Inoko83, Vladimir Janout84, Susana Jiménez-Murcia60,61, Antonio Julià85, Gursharan Kalsi3, Deborah Kaminská86, Leila Karhunen87, Andreas Karwautz88, Martien J H Kas19,89, James L Kennedy90,91,92, Anna Keski-Rahkonen93, Kirsty Kiezebrink94, Youl-Ri Kim95, Kelly L Klump96, Gun Peggy S Knudsen97, Maria C La Via1, Stephanie Le Hellard98,99,100, Robert D Levitan90,91,92, Dong Li74, Lisa Lilenfeld101, Bochao Danae Lin19, Jolanta Lissowska102, Jurjen Luykx19, Pierre J Magistretti103,104, Mario Maj105, Katrin Mannik57,106, Sara Marsal85, Christian R Marshall107, Morten Mattingsdal108, Sara McDevitt109,110, Peter McGuffin3, Andres Metspalu57,111, Ingrid Meulenbelt112, Nadia Micali113,114, Karen Mitchell115,116, Alessio Maria Monteleone105, Palmiero Monteleone117, Benedetta Nacmias118, Marie Navratilova65, Ioanna Ntalla43, Julie K O'Toole119, Roel A Ophoff120,121, Leonid Padyukov122, Aarno Palotie58,123,124, Jacques Pantel27, Hana Papezova86, Dalila Pinto80, Raquel Rabionet125,126,127, Anu Raevuori93, Nicolas Ramoz72, Ted Reichborn-Kjennerud97,128, Valdo Ricca129, Samuli Ripatti130, Franziska Ritschel26,131, Marion Roberts3, Alessandro Rotondo132, Dan Rujescu70, Filip Rybakowski133, Paolo Santonastaso134, André Scherag135, Stephen W Scherer136,137, Ulrike Schmidt138, Nicholas J Schork139, Alexandra Schosser140, Jochen Seitz30, Lenka Slachtova141, P Eline Slagboom142, Margarita C T Slof-Op't Landt143,144, Agnieszka Slopien145, Sandro Sorbi118,146, Beata Świątkowska147, Jin P Szatkiewicz7, Ioanna Tachmazidou28, Elena Tenconi44, Alfonso Tortorella148,149, Federica Tozzi150, Janet Treasure138, Artemis Tsitsika151, Marta Tyszkiewicz-Nwafor145, Konstantinos Tziouvas152, Annemarie A van Elburg20,153, Eric F van Furth143,144, Gudrun Wagner88, Esther Walton26, Elisabeth Widen123, Eleftheria Zeggini28,76, Stephanie Zerwas1, Stephan Zipfel154, Andrew W Bergen155,156, Joseph M Boden157, Harry Brandt158, Steven Crawford158, Katherine A Halmi159, L John Horwood157, Craig Johnson160, Allan S Kaplan90,91,92, Walter H Kaye161, James Mitchell162, Catherine M Olsen163, John F Pearson164, Nancy L Pedersen8, Michael Strober165,166, Thomas Werge167, David C Whiteman163, D Blake Woodside91,92,168,169, Jakob Grove13,170,171,172, Anjali K Henders173, Janne T Larsen170,174,175, Richard Parker9, Liselotte V Petersen170,174,175, Jennifer Jordan176,177, Martin A Kennedy178, Andreas Birgegård8,14,15, Paul Lichtenstein8, Claes Norring14,15, Mikael Landén8,179, Preben Bo Mortensen170,174,175, Renato Polimanti180,181, Jeanette N McClintick182, Amy E Adkins46,47, Fazil Aliev46,183, Silviu-Alin Bacanu184,185,186, Anthony Batzler187, Sarah Bertelsen188, Joanna M Biernacka189,190, Tim B Bigdeli191, Li-Shiun Chen2, Toni-Kim Clarke192, Franziska Degenhardt193, Anna R Docherty194, Alexis C Edwards185,186, Jerome C Foo195, Louis Fox2, Josef Frank195, Laura M Hack55, Annette M Hartmann70, Sarah M Hartz2, Stefanie Heilmann-Heimbach193, Colin Hodgkinson196, Per Hoffmann33,67,197, Jouke-Jan Hottenga198, Bettina Konte70, Jari Lahti199, Marius Lahti-Pulkkinen200, Dongbing Lai201, Lannie Ligthart198, Anu Loukola123, Brion S Maher202, Hamdi Mbarek198, Andrew M McIntosh203, Matthew B McQueen204, Jacquelyn L Meyers205, Yuri Milaneschi206, Teemu Palviainen123, Roseann E Peterson185,186, Euijung Ryu189, Nancy L Saccone207, Jessica E Salvatore46,185,186, Sandra Sanchez-Roige161, Melanie Schwandt208, Richard Sherva209, Fabian Streit195, Jana Strohmaier195, Nathaniel Thomas46,47, Jen-Chyong Wang188, Bradley T Webb184,185,186, Robbee Wedow5,6,210,211, Leah Wetherill201, Amanda G Wills212, Hang Zhou180,181, Jason D Boardman213,214, Danfeng Chen6, Doo-Sup Choi215, William E Copeland216, Robert C Culverhouse217, Norbert Dahmen218, Louisa Degenhardt219, Benjamin W Domingue220, Mark A Frye190, Wolfgang Gäebel221, Caroline Hayward222, Marcus Ising223, Margaret Keyes224, Falk Kiefer225, Gabriele Koller226, John Kramer227, Samuel Kuperman227, Susanne Lucae223, Michael T Lynskey228, Wolfgang Maier229, Karl Mann225, Satu Männistö230, Bertram Müller-Myhsok231, Alison D Murray232, John I Nurnberger201,233, Ulrich Preuss234,235, Katri Räikkönen200, Maureen D Reynolds236, Monika Ridinger237, Norbert Scherbaum238, Marc A Schuckit161, Michael Soyka239,240, Jens Treutlein195, Stephanie H Witt195, Norbert Wodarz241, Peter Zill242, Daniel E Adkins194,243, Dorret I Boomsma198, Laura J Bierut2, Sandra A Brown161,244, Kathleen K Bucholz2, E Jane Costello245, Harriet de Wit246, Nancy Diazgranados247, Johan G Eriksson248,249, Lindsay A Farrer209,250,251,252,253, Tatiana M Foroud201, Nathan A Gillespie185, Alison M Goate188, David Goldman196,254, Richard A Grucza2, Dana B Hancock255, Kathleen Mullan Harris256,257, Victor Hesselbrock258, John K Hewitt259, Christian J Hopfer260, William G Iacono224, Eric O Johnson255,261, Victor M Karpyak190, Kenneth S Kendler185,186, Henry R Kranzler262,263, Kenneth Krauter264, Penelope A Lind9, Matt McGue224, James MacKillop265,266, Pamela A F Madden2, Hermine H Maes185, Patrik K E Magnusson8, Elliot C Nelson2, Markus M Nöthen193, Abraham A Palmer161,267, Brenda W J H Penninx268, Bernice Porjesz205, John P Rice2, Marcella Rietschel195, Brien P Riley184,185,186, Richard J Rose269, Pei-Hong Shen196, Judy Silberg185,186, Michael C Stallings259, Ralph E Tarter236, Michael M Vanyukov236, Scott Vrieze224, Tamara L Wall161, John B Whitfield9, Hongyu Zhao270, Benjamin M Neale5,6, Tracey D Wade271, Andrew C Heath2, Grant W Montgomery9,173,272, Nicholas G Martin9, Patrick F Sullivan1,7,8, Jaakko Kaprio93,123, Gerome Breen3,4, Joel Gelernter180,181,273,274, Howard J Edenberg182,201, Cynthia M Bulik1,8,275, Arpana Agrawal2.
Abstract
Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.Entities:
Keywords: eating disorders; genetic correlation; substance use
Mesh：
Year: 2020 PMID： 32064741 PMCID： PMC7429266 DOI： 10.1111/adb.12880
Source DB: PubMed Journal: Addict Biol ISSN： 1355-6215 Impact factor: 4.093