Clinical analysis of application of antibiotic bone cement spacer combined with membrane induction technology in treatment of osteomyelitis after femoral intramedullary nail operation - A case series.

Clinical analysis of antibiotic bone cement spacer combined with membrane induction technology in the treatment of osteomyelitis after intramedullary nail fixation operation for femoral shaft fracture was retrospectively performed on 12 cases in Department of Orthopaedics Centre, Renmin Hospital, Hubei University of Medicine from February 2013 to November 2016. The healing time of bone defect, infection recurrence and other complications were observed. Membrane induced series treatment scheme was given to all patients. Membrane-induced sequence therapy consisted of the first stage which included complete debridement, removal of the original internal fixation of intramedullary nail, intraoperative preparation of antibiotic bone cement rod into the medullary cavity and full drainage. The second stage included replacement of the interlocking intramedullary nail after infection control and autologous iliac bone graft was then used at the bone defect. Followup visits for bone situations were conducted for all the cases and the duration was 12-35 min (25.75 min on average). Fractures of all patients healed clinically. The healing duration was 4-11 min (7.33 min on average).After treatment, patients had no significant shortening of the limbs and their gait was normal at 12 months follow-up. This study is of femoral shaft fracture with no involvement of the joints and range of movement was not measured. No apparent relevant complications were seen.