Weiqun Ao1, Xiangdong Bao2, Guoqun Mao1, Guangzhao Yang1, Jian Wang1, Jinwen Hu3. 1. Department of Radiology, Tongde Hospital of Zhejiang Provice, Hangzhou, China. 2. Department of Anorectal Surgery, Tongde Hospital of Zhejiang Provice, Hangzhou, China. 3. Department of Radiology, Shanghai Putuo People's Hospital, Shanghai, China.
Abstract
PURPOSE: To explore the value of the apparent diffusion coefficient (ADC) in assessing preoperative T staging of low rectal cancer and the correlation between ADC value and Ki-67 expression. METHODS: Data on 77 patients with a proven pathology of low rectal cancer were retrospectively analyzed. All patients underwent a magnetic resonance imaging scan 1 week prior to operation, and the mean ADC value was measured. All tumors were fully removed, and pathologic staging was determined. The Ki-67 expression was determined using immunohistochemical methods in all patients. The correlation between Ki-67 expression and ADC features was studied. RESULTS: A total of 77 patients with low rectal cancer were included in the study. The pathology type was adenocarcinoma. The numbers of patients with pathological stages T1, T2, T3, and T4 were 9, 23, 32, and 13, respectively. The ADC value of all tumors ranged from 0.60 to 1.20 mm2/s. The average Ki-67 proliferation index was 55.3% ± 20.2%. A significant difference was observed between the preoperative ADC value and pathological T staging of low rectal cancer (P < .01). The more advanced the T stage, the lower the detected ADC values were. A negative correlation was noted between the preoperative ADC value and Ki-67 proliferation index of rectal cancer (r = -0.71, P < .01). When the Ki-67 proliferation index increased, lower ADC values were detected. CONCLUSION: The ADC values can provide useful information on preoperative tumor staging and may facilitate evaluation of the biological behavior of low rectal cancer. The ADC values should be considered a sensitive image biomarker of rectal cancer.
PURPOSE: To explore the value of the apparent diffusion coefficient (ADC) in assessing preoperative T staging of low rectal cancer and the correlation between ADC value and Ki-67 expression. METHODS: Data on 77 patients with a proven pathology of low rectal cancer were retrospectively analyzed. All patients underwent a magnetic resonance imaging scan 1 week prior to operation, and the mean ADC value was measured. All tumors were fully removed, and pathologic staging was determined. The Ki-67 expression was determined using immunohistochemical methods in all patients. The correlation between Ki-67 expression and ADC features was studied. RESULTS: A total of 77 patients with low rectal cancer were included in the study. The pathology type was adenocarcinoma. The numbers of patients with pathological stages T1, T2, T3, and T4 were 9, 23, 32, and 13, respectively. The ADC value of all tumors ranged from 0.60 to 1.20 mm2/s. The average Ki-67 proliferation index was 55.3% ± 20.2%. A significant difference was observed between the preoperative ADC value and pathological T staging of low rectal cancer (P < .01). The more advanced the T stage, the lower the detected ADC values were. A negative correlation was noted between the preoperative ADC value and Ki-67 proliferation index of rectal cancer (r = -0.71, P < .01). When the Ki-67 proliferation index increased, lower ADC values were detected. CONCLUSION: The ADC values can provide useful information on preoperative tumor staging and may facilitate evaluation of the biological behavior of low rectal cancer. The ADC values should be considered a sensitive image biomarker of rectal cancer.
Entities:
Keywords:
Ki-67; T staging; apparent diffusion coefficient; low rectal cancer; magnetic resonance imaging
Authors: Alexey Surov; Hans-Jonas Meyer; Maciej Pech; Maciej Powerski; Jasan Omari; Andreas Wienke Journal: Int J Colorectal Dis Date: 2021-06-29 Impact factor: 2.571