Arnaud Gacouin1, Benoit Painvin2, Valentin Coirier2, Quentin Quelven2, Boris Delange2, Vincent Joussellin2, Félicie Belicard2, Floriane L'her2, Adel Maamar2, Yves Le Tulzo3, Jean Marc Tadié3. 1. CHU Rennes, Maladies Infectieuses et Réanimation Médicale, F-35033 Rennes, France; Université Rennes1, Faculté de Médecine, Biosit, F-35043 Rennes, France; Inserm-CIC-1414, Faculté de Médecine, Université Rennes I, IFR 140, F-35033 Rennes, France. Electronic address: arnaud.gacouin@chu-rennes.fr. 2. CHU Rennes, Maladies Infectieuses et Réanimation Médicale, F-35033 Rennes, France; Université Rennes1, Faculté de Médecine, Biosit, F-35043 Rennes, France. 3. CHU Rennes, Maladies Infectieuses et Réanimation Médicale, F-35033 Rennes, France; Université Rennes1, Faculté de Médecine, Biosit, F-35043 Rennes, France; Inserm-CIC-1414, Faculté de Médecine, Université Rennes I, IFR 140, F-35033 Rennes, France.
Abstract
PURPOSE: Alcohol dependence is associated with poor prognosis in the intensive care unit (ICU), but it remains uncertain whether moderate alcohol consumption negatively affects the prognosis of critically ill patients admitted with infection. MATERIALS AND METHODS: In a prospective observational cohort study performed in 478 patients admitted with documented infection, mortality at day 28 in the group of abstainers and nontrauma patients with estimated alcohol consumption lower than 100 g/week was compared with that in non-alcohol-dependent patients with estimated alcohol consumption between 100 and 350 g/week. RESULTS: In 97 patients (20%), alcohol consumption was estimated to be over 100 g/week, and in 391 patients (80%), alcohol consumption was estimated to be 100 g/week or less. The pathogens identified did not significantly differ between the two groups of patients. After adjusted analysis, alcohol consumption between 100 and 350 g/week remained significantly associated with mortality at day 28 (hazard ratio (HR): 1.67; 95% confidence interval (CI): 1.01-2.77; p = .04). CONCLUSION: Alcohol consumption between 100 and 350 g/week was independently associated with mortality at day 28. Our results suggest that in critically ill patients admitted with infection, moderate alcohol consumption is associated with a poorer prognosis.
PURPOSE:Alcohol dependence is associated with poor prognosis in the intensive care unit (ICU), but it remains uncertain whether moderate alcohol consumption negatively affects the prognosis of critically illpatients admitted with infection. MATERIALS AND METHODS: In a prospective observational cohort study performed in 478 patients admitted with documented infection, mortality at day 28 in the group of abstainers and nontrauma patients with estimated alcohol consumption lower than 100 g/week was compared with that in non-alcohol-dependent patients with estimated alcohol consumption between 100 and 350 g/week. RESULTS: In 97 patients (20%), alcohol consumption was estimated to be over 100 g/week, and in 391 patients (80%), alcohol consumption was estimated to be 100 g/week or less. The pathogens identified did not significantly differ between the two groups of patients. After adjusted analysis, alcohol consumption between 100 and 350 g/week remained significantly associated with mortality at day 28 (hazard ratio (HR): 1.67; 95% confidence interval (CI): 1.01-2.77; p = .04). CONCLUSION:Alcohol consumption between 100 and 350 g/week was independently associated with mortality at day 28. Our results suggest that in critically illpatients admitted with infection, moderate alcohol consumption is associated with a poorer prognosis.
Authors: Małgorzata Łowicka-Smolarek; Izabela Kokoszka-Bargieł; Małgorzata Knapik; Konstanty Śmietanka; Piotr Dyrda; Mateusz Możdżeń; Magdalena Kurczab; Jarosław Borkowski; Piotr Knapik Journal: Int J Environ Res Public Health Date: 2022-05-12 Impact factor: 4.614
Authors: Fatima Mougharbel; Hugues Sampasa-Kanyinga; Brandon Heidinger; Kim Corace; Hayley A Hamilton; Gary S Goldfield Journal: Front Public Health Date: 2021-06-25