| Literature DB >> 32061845 |
Mantosh Kumar Singh1, Sai Kiran S S Pindiprolu2, Bharat Kumar Reddy Sanapalli3, Vidyasrilekha Yele4, G N K Ganesh5.
Abstract
The present research reports the beneficial effects of surface modified chitosan and tumor-homing peptide conjugated liposomes of capecitabine (CAP) for treating breast cancer. Liposomal formulation of CAP was prepared by film hydration method using cholesterol-THP conjugate (CTHP-CAP-LPs) to achieve active targeting through HER2 receptors. CTHP-CAP-LPs significantly improved the specificity and efficacy of CAP by improving cell uptake, cytotoxicity and tumor regression in tumor bearing mice. CTHP-CAP-LPs, therefore, is a promising approach to improve the anticancer effects of CAP.Entities:
Keywords: Active targeting; Breast cancer; Cell uptake; Chitosan; HER2 receptor
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Year: 2020 PMID： 32061845 DOI： 10.1016/j.ijbiomac.2020.02.131
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953