Kerstin Hellgren1, Lena Jacobson2, Paolo Frumento3, Jenny Bolk4, Ulrika Ådén5, Melissa E Libertus6, Mariagrazia Benassi7. 1. Department of Clinical Neuroscience, Division of Ophthalmology and Vision, Marianne Bernadotte Centre, Karolinska Institutet, Karolinska University Hospital, Astrid Lindgren Children's Hospital, Stockholm, Sweden. Electronic address: kerstin.hellgren@ki.se. 2. Department of Clinical Neuroscience, Division of Ophthalmology and Vision, Marianne Bernadotte Centre, Karolinska Institutet, Stockholm, Sweden. 3. Institute of Environmental Medicine, Unit of Biostatistics, Karolinska Institutet, Stockholm, Sweden. 4. Clinical Epidemiology Unit, Department of Medicine-Solna, Karolinska Institutet, Stockholm, Sweden. 5. Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. 6. Department of Psychology, Learning Research and Development Center, University of Pittsburgh, Pittsburgh, Pennsylvania. 7. Department of Psychology, University of Bologna, Italy.
Abstract
PURPOSE: To investigate whether a questionnaire can identify cerebral visual impairment (CVI) in a group of 6.5-year-old children born extremely preterm (EPT) as accurately as direct assessments. METHODS: This prospective population-based study included 120 children born before 27 weeks' gestational age (66 males; mean, 25.4 ± 1.0 weeks) and 97 full-term controls (56 males; mean, 39.9 ± 1.1 weeks) at the age of 6.5 years, as part of the Extremely Preterm Infants in Sweden Study (EXPRESS). A questionnaire for detection of CVI was evaluated and compared with visual, perceptual, and cognitive assessments. RESULTS: Parents of children born EPT reported more CVI features than the parents of control children, with median sum scores of 25 (95% CI, 18.1-31.9) and 11 (95% CI, 8.8-13.2), respectively (P < 0.001), and a median difference of 14 (95% CI, 6.6-21.4). Low rates of reported CVI features were significantly associated with better results from direct assessments within the EPT group and with less pronounced differences compared to controls. CONCLUSIONS: The questionnaire discriminated well between children born EPT and controls, and the scores were congruent with other evidence of visual, perceptual, and cognitive deficits. The easily used questionnaire compared favorably with direct assessment in identifying CVI in children born EPT and also provides valuable information to clinicians, and parents about the daily life problems associated with CVI.
PURPOSE: To investigate whether a questionnaire can identify cerebral visual impairment (CVI) in a group of 6.5-year-old children born extremely preterm (EPT) as accurately as direct assessments. METHODS: This prospective population-based study included 120 children born before 27 weeks' gestational age (66 males; mean, 25.4 ± 1.0 weeks) and 97 full-term controls (56 males; mean, 39.9 ± 1.1 weeks) at the age of 6.5 years, as part of the Extremely Preterm Infants in Sweden Study (EXPRESS). A questionnaire for detection of CVI was evaluated and compared with visual, perceptual, and cognitive assessments. RESULTS: Parents of children born EPT reported more CVI features than the parents of control children, with median sum scores of 25 (95% CI, 18.1-31.9) and 11 (95% CI, 8.8-13.2), respectively (P < 0.001), and a median difference of 14 (95% CI, 6.6-21.4). Low rates of reported CVI features were significantly associated with better results from direct assessments within the EPT group and with less pronounced differences compared to controls. CONCLUSIONS: The questionnaire discriminated well between children born EPT and controls, and the scores were congruent with other evidence of visual, perceptual, and cognitive deficits. The easily used questionnaire compared favorably with direct assessment in identifying CVI in children born EPT and also provides valuable information to clinicians, and parents about the daily life problems associated with CVI.
Authors: Frouke N Boonstra; Daniëlle G M Bosch; Christiaan J A Geldof; Catharina Stellingwerf; Giorgio Porro Journal: Front Hum Neurosci Date: 2022-06-30 Impact factor: 3.473
Authors: Ann Hellström; Lena Jacobson; Abbas Al-Hawasi; Lena Hellström-Westas; Alexander Rakow; Mats Johnson; Karin Sävman; Gerd Holmstrom; Eva Larsson; Lotta Gränse; Marie Saric; Birgitta Sunnqvist; Lois Smith; Anna-Lena Hård; Eva Morsing; Pia Lundgren Journal: BMJ Open Date: 2022-08-03 Impact factor: 3.006