| Literature DB >> 32061543 |
Paramita Chakraborty1, Shikhar Mehrotra2.
Abstract
To keep autoreactive T cells under control in SLE patients, immunosuppressive regimens are used, which can increase susceptibility to bacterial and viral infections. Recently, Katsuyama et al., demonstrated that the CD38/NAD/Sirtuin1/EZH2 axis reduces cytolytic CD8+ T cell function and might be targeted to overcome incidence of infections.Entities:
Keywords: CD38; EZH2; SLE; T cells; methylation
Year: 2020 PMID： 32061543 DOI： 10.1016/j.it.2020.01.008
Source DB: PubMed Journal: Trends Immunol ISSN： 1471-4906 Impact factor: 16.687