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Literature DB >> 32061306

Mechanistic Links between Obesity, Insulin, and Cancer.

Abstract

Obesity and type 2 diabetes (T2D) increase the prevalence and worsen the prognosis of more than a dozen tumor types; however, the mechanism for this association remains hotly debated. Here we discuss a potential role for insulin as the key hormonal mediator of tumor metabolism and growth in obesity-associated insulin resistance.

Entities: Chemical Disease Gene Species

Keywords: diabetes; insulin resistance; metabolism; obesity

Mesh：

Substances：

Year: 2020 PMID： 32061306 PMCID： PMC7214048 DOI： 10.1016/j.trecan.2019.12.003

Source DB: PubMed Journal: Trends Cancer ISSN： 2405-8025

15 in total

1. PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.

Authors: Mami Morita; Taku Sato; Miyuki Nomura; Yoshimi Sakamoto; Yui Inoue; Ryota Tanaka; Shigemi Ito; Koreyuki Kurosawa; Kazunori Yamaguchi; Yuki Sugiura; Hiroshi Takizaki; Yoji Yamashita; Ryuichi Katakura; Ikuro Sato; Masaaki Kawai; Yoshinori Okada; Hitomi Watanabe; Gen Kondoh; Shoko Matsumoto; Ayako Kishimoto; Miki Obata; Masaki Matsumoto; Tatsuro Fukuhara; Hozumi Motohashi; Makoto Suematsu; Masaaki Komatsu; Keiichi I Nakayama; Toshio Watanabe; Tomoyoshi Soga; Hiroshi Shima; Makoto Maemondo; Nobuhiro Tanuma
Journal: Cancer Cell Date: 2018-03-12 Impact factor: 31.743

2. Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer.

Authors: Yongliang Wang; Ali R Nasiri; William E Damsky; Curtis J Perry; Xian-Man Zhang; Aviva Rabin-Court; Michael N Pollak; Gerald I Shulman; Rachel J Perry
Journal: Cell Rep Date: 2018-07-03 Impact factor: 9.423

Review 3. Energy balance, host-related factors, and cancer progression.

Authors: Stephen D Hursting; Nathan A Berger
Journal: J Clin Oncol Date: 2010-08-09 Impact factor: 44.544

Review 4. Obesity and cancer risk: Emerging biological mechanisms and perspectives.

Authors: Konstantinos I Avgerinos; Nikolaos Spyrou; Christos S Mantzoros; Maria Dalamaga
Journal: Metabolism Date: 2018-11-13 Impact factor: 8.694

5. Cancer incidence in persons with type 1 diabetes: a five-country study of 9,000 cancers in type 1 diabetic individuals.

Authors: Bendix Carstensen; Stephanie H Read; Søren Friis; Reijo Sund; Ilmo Keskimäki; Ann-Marie Svensson; Rickard Ljung; Sarah H Wild; Joannes J Kerssens; Jessica L Harding; Dianna J Magliano; Soffia Gudbjörnsdottir
Journal: Diabetologia Date: 2016-02-29 Impact factor: 10.122

Review 6. Exercise and cancer: from "healthy" to "therapeutic"?

Authors: Manja Idorn; Per Thor Straten
Journal: Cancer Immunol Immunother Date: 2017-03-21 Impact factor: 6.968

7. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors.

Authors: Benjamin D Hopkins; Chantal Pauli; Xing Du; Diana G Wang; Xiang Li; David Wu; Solomon C Amadiume; Marcus D Goncalves; Cindy Hodakoski; Mark R Lundquist; Rohan Bareja; Yan Ma; Emily M Harris; Andrea Sboner; Himisha Beltran; Mark A Rubin; Siddhartha Mukherjee; Lewis C Cantley
Journal: Nature Date: 2018-07-04 Impact factor: 49.962

8. Sex differences in the association between diabetes and cancer: a systematic review and meta-analysis of 121 cohorts including 20 million individuals and one million events.

Authors: Toshiaki Ohkuma; Sanne A E Peters; Mark Woodward
Journal: Diabetologia Date: 2018-07-20 Impact factor: 10.122

9. Obesity-associated, but not obesity-independent, tumors respond to insulin by increasing mitochondrial glucose oxidation.

Authors: Aviva Rabin-Court; Marcos R Rodrigues; Xian-Man Zhang; Rachel J Perry
Journal: PLoS One Date: 2019-06-12 Impact factor: 3.240

10. The beneficial effects of metformin on cancer prevention and therapy: a comprehensive review of recent advances.

Authors: Pouya Saraei; Ilia Asadi; Muhammad Azam Kakar; Nasroallah Moradi-Kor
Journal: Cancer Manag Res Date: 2019-04-17 Impact factor: 3.989

16 in total

1. Dietary Insulinemic Potential and Risk of Total and Cause-Specific Mortality in the Nurses' Health Study and the Health Professionals Follow-up Study.

Authors: Yi Wan; Fred K Tabung; Dong Hoon Lee; Teresa T Fung; Walter C Willett; Edward L Giovannucci
Journal: Diabetes Care Date: 2022-02-01 Impact factor: 19.112

Review 2. Metabolic dysfunction and obesity-related cancer: Beyond obesity and metabolic syndrome.

Authors: Sheetal Hardikar; Mary C Playdon; Prasoona Karra; Maci Winn; Svenja Pauleck; Alicja Bulsiewicz-Jacobsen; Lacie Peterson; Adriana Coletta; Jennifer Doherty; Cornelia M Ulrich; Scott A Summers; Marc Gunter
Journal: Obesity (Silver Spring) Date: 2022-07 Impact factor: 9.298

3. Systemic Ablation of Camkk2 Impairs Metastatic Colonization and Improves Insulin Sensitivity in TRAMP Mice: Evidence for Cancer Cell-Extrinsic CAMKK2 Functions in Prostate Cancer.

Authors: Thomas L Pulliam; Dominik Awad; Jenny J Han; Mollianne M Murray; Jeffrey J Ackroyd; Pavithr Goli; Jonathan S Oakhill; John W Scott; Michael M Ittmann; Daniel E Frigo
Journal: Cells Date: 2022-06-10 Impact factor: 7.666

4. Creatine-mediated crosstalk between adipocytes and cancer cells regulates obesity-driven breast cancer.

Authors: Olivia A Maguire; Sarah E Ackerman; Sarah K Szwed; Aarthi V Maganti; François Marchildon; Xiaojing Huang; Daniel J Kramer; Adriana Rosas-Villegas; Rebecca G Gelfer; Lauren E Turner; Victor Ceballos; Asal Hejazi; Bozena Samborska; Janane F Rahbani; Christien B Dykstra; Matthew G Annis; Ji-Dung Luo; Thomas S Carroll; Caroline S Jiang; Andrew J Dannenberg; Peter M Siegel; Sarah A Tersey; Raghavendra G Mirmira; Lawrence Kazak; Paul Cohen
Journal: Cell Metab Date: 2021-02-16 Impact factor: 27.287

Review 5. Insulin and cancer: a tangled web.

Authors: Brooks P Leitner; Stephan Siebel; Ngozi D Akingbesote; Xinyi Zhang; Rachel J Perry
Journal: Biochem J Date: 2022-03-18 Impact factor: 3.766