Literature DB >> 32060111

Primary cutaneous Aspergillus fumigatus infection in immunocompetent host.

Pradeep Kumar Mada1, Daniel Alexander Saldaña Koppel2, Majd Al Shaarani3, Andrew Stevenson Joel Chandranesan4.   

Abstract

Primary cutaneous aspergillosis (PCA) occurs through inoculation of fungal spores directly into the skin from the environment through disrupted skin such as in burns, surgery or penetrating trauma patients. Most cases reported in literature were in the immunocompromised, rarely in immunocompetent patients. The characteristic lesion of cutaneous aspergillosis is a black eschar on a red plaque, or nodule at the site of skin injury. The diagnosis of PCA can be made by identifying hyphal forms on routine H&E staining or special stains such as periodic acid-Schiff or Gomori methenamine-silver stains on skin biopsy and by fungal cultures. We report a case of an 80-year-old farmer who developed cutaneous aspergillosis after a surgical procedure without any systemic spread. The diagnosis was made by histopathology and tissue fungal cultures. He was treated with incision and drainage followed by oral voriconazole for 4 weeks; which led to clinical recovery. © BMJ Publishing Group Limited 2020. No commercial re-use. See rights and permissions. Published by BMJ.

Entities:  

Keywords:  dermatological; drugs: infectious diseases; exposures; pathology; skin

Mesh:

Substances:

Year:  2020        PMID: 32060111      PMCID: PMC7046428          DOI: 10.1136/bcr-2019-233020

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  11 in total

1.  Primary cutaneous aspergillosis.

Authors:  S Munn; F Keane; F Child; J Philpott-Howard; A Du Vivier
Journal:  Br J Dermatol       Date:  1999-08       Impact factor: 9.302

2.  Primary cutaneous aspergillosis.

Authors:  P V S Prasad; A Babu; P K Kaviarasan; C Anandhi; P Viswanathan
Journal:  Indian J Dermatol Venereol Leprol       Date:  2005 Mar-Apr       Impact factor: 2.545

3.  Topical nystatin powder in severe burns: a new treatment for angioinvasive fungal infections refractory to other topical and systemic agents.

Authors:  J P Barret; P I Ramzy; J P Heggers; C Villareal; D N Herndon; M H Desai
Journal:  Burns       Date:  1999-09       Impact factor: 2.744

4.  Primary cutaneous aspergillosis: our experience in 10 years.

Authors:  A Chakrabarti; V Gupta; G Biswas; B Kumar; V K Sakhuja
Journal:  J Infect       Date:  1998-07       Impact factor: 6.072

5.  Damage to Aspergillus fumigatus and Rhizopus oryzae hyphae by oxidative and nonoxidative microbicidal products of human neutrophils in vitro.

Authors:  R D Diamond; R A Clark
Journal:  Infect Immun       Date:  1982-11       Impact factor: 3.441

6.  "Fruiting bodies" of aspergillus on the skin of a burned patient.

Authors:  T W Panke; A T McManus; C G McLeod
Journal:  Am J Clin Pathol       Date:  1978-02       Impact factor: 2.493

7.  Primary cutaneous aspergillosis due to Aspergillus niger in an immunocompetent patient.

Authors:  S Mohapatra; I Xess; J V Swetha; N Tanveer; D Asati; M Ramam; M K Singh
Journal:  Indian J Med Microbiol       Date:  2009 Oct-Dec       Impact factor: 0.985

8.  Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes.

Authors:  A Schaffner; H Douglas; A Braude
Journal:  J Clin Invest       Date:  1982-03       Impact factor: 14.808

Review 9.  Cutaneous Invasive Aspergillosis: Retrospective Multicenter Study of the French Invasive-Aspergillosis Registry and Literature Review.

Authors:  Céline Bernardeschi; Francoise Foulet; Saskia Ingen-Housz-Oro; Nicolas Ortonne; Karine Sitbon; Gaëlle Quereux; Olivier Lortholary; Olivier Chosidow; Stéphane Bretagne
Journal:  Medicine (Baltimore)       Date:  2015-07       Impact factor: 1.889

Review 10.  Factors affecting patient outcome in primary cutaneous aspergillosis.

Authors:  Alexander M Tatara; Antonios G Mikos; Dimitrios P Kontoyiannis
Journal:  Medicine (Baltimore)       Date:  2016-06       Impact factor: 1.889

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  1 in total

1.  Clinical Characteristics of Bloodstream Infection in Immunosuppressed Patients: A 5-Year Retrospective Cohort Study.

Authors:  Hongxia Lin; Lili Yang; Jie Fang; Yulian Gao; Haixing Zhu; Shengxiong Zhang; Hanssa Dwarka Summah; Guochao Shi; Jingyong Sun; Lei Ni; Yun Feng
Journal:  Front Cell Infect Microbiol       Date:  2022-04-04       Impact factor: 6.073

  1 in total

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