Jasmina Poluga1, Aleksandra Barac2, Natasa Katanic3, Salvatore Rubino4, Branko Milosevic5, Aleksandar Urosevic6, Nikola Mitrovic7, Ivana Kelic8, Jelena Micic9, Goran Stevanovic10. 1. Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia. poluga@eunet.rs. 2. Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia. abarac@jidc.org. 3. Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia. katanicn@gmail.com. 4. Department of Biomedical Sciences, University of Sassari, Sassari, Italy. rubino@uniss.it. 5. Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia. milosevicb@yaho.com. 6. Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia. urosevicaleks@yahoo.com. 7. Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia. mitrovicnik@gmail.com. 8. Institute for Public Health "Dr Milan Jovanovic Batut", Belgrade, Serbia. kelicivanas@gmail.com. 9. Clinic for Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia. jdmicic@yahoo.com. 10. Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Belgrade, Serbia. goran_drste@yahoo.com.
Abstract
INTRODUCTION: In the Europe, the number of tick-borne encephalitis (TBE) has been increased in the last decade, and the number of endemic areas has been also increased and is still growing. In the present case series, we present clinical and socio-epidemiological data of patients with TBE hospitalized in the period of TBE virus epidemic in Serbia. METHODOLOGY: A case series was conducted in Serbia in 2017. Patients with confirmed TBE were included in the study. Biochemical and serological analysis of blood and CSF, as well as radiological imaging (CT and MRI) were done. RESULTS: In total, 10 patients with TBE were included in the study. M:F ratio was 1.5:1, while average age was 45.1 years. Half of the patients had severe clinical picture. Endocranial CT scan and MRI did not reveal any abnormality, except in the patient with the most severe CNS infection (meningoencephalomyelitis). Mean value of sedimentation and CRP was slightly elevated (29.6 mm/1hours and 20.1 mg/L, respectively) in 80% of the patients, although elevation was almost negligible. The average number of leucocytes in the cerebrospinal fluid (CSF) was 171×106/L, the mean value of the CSF protein was 1.1g/L. There were no fatal outcomes. CONCLUSION: Since other CNS infections have similar clinical picture and CSF finding as TBE, serological analysis for TBE should be included in routine diagnostic practice. Copyright (c) 2019 Jasmina Poluga, Aleksandra Barac, Natasa Katanic, Salvatore Rubino, Branko Milosevic, Aleksandar Urosevic, Nikola Mitrovic, Ivana Kelic, Jelena Micic, Goran Stevanovic.
INTRODUCTION: In the Europe, the number of tick-borne encephalitis (TBE) has been increased in the last decade, and the number of endemic areas has been also increased and is still growing. In the present case series, we present clinical and socio-epidemiological data of patients with TBE hospitalized in the period of TBE virus epidemic in Serbia. METHODOLOGY: A case series was conducted in Serbia in 2017. Patients with confirmed TBE were included in the study. Biochemical and serological analysis of blood and CSF, as well as radiological imaging (CT and MRI) were done. RESULTS: In total, 10 patients with TBE were included in the study. M:F ratio was 1.5:1, while average age was 45.1 years. Half of the patients had severe clinical picture. Endocranial CT scan and MRI did not reveal any abnormality, except in the patient with the most severe CNS infection (meningoencephalomyelitis). Mean value of sedimentation and CRP was slightly elevated (29.6 mm/1hours and 20.1 mg/L, respectively) in 80% of the patients, although elevation was almost negligible. The average number of leucocytes in the cerebrospinal fluid (CSF) was 171×106/L, the mean value of the CSF protein was 1.1g/L. There were no fatal outcomes. CONCLUSION: Since other CNS infections have similar clinical picture and CSF finding as TBE, serological analysis for TBE should be included in routine diagnostic practice. Copyright (c) 2019 Jasmina Poluga, Aleksandra Barac, Natasa Katanic, Salvatore Rubino, Branko Milosevic, Aleksandar Urosevic, Nikola Mitrovic, Ivana Kelic, Jelena Micic, Goran Stevanovic.
Authors: Michael Kunze; Pavle Banović; Petra Bogovič; Violeta Briciu; Rok Čivljak; Gerhard Dobler; Adriana Hristea; Jana Kerlik; Suvi Kuivanen; Jan Kynčl; Anne-Mette Lebech; Lars Lindquist; Iwona Paradowska-Stankiewicz; Srđan Roglić; Dita Smíšková; Franc Strle; Olli Vapalahti; Nenad Vranješ; Nataliya Vynograd; Joanna Maria Zajkowska; Andreas Pilz; Andreas Palmborg; Wilhelm Erber Journal: Microorganisms Date: 2022-06-24
Authors: Pavle Banović; Adrian Alberto Díaz-Sánchez; Clemence Galon; Angélique Foucault-Simonin; Verica Simin; Dragana Mijatović; Luka Papić; Alejandra Wu-Chuang; Dasiel Obregón; Sara Moutailler; Alejandro Cabezas-Cruz Journal: One Health Date: 2021-06-01
Authors: Ana Vasić; Jovana Bjekić; Gorana Veinović; Darko Mihaljica; Ratko Sukara; Jasmina Poluga; Saša R Filipović; Snežana Tomanović Journal: Int J Environ Res Public Health Date: 2022-01-13 Impact factor: 3.390