Literature DB >> 32058929

Long non-coding RNAs in immune regulation and their potential as therapeutic targets.

Dinesh Babu Uthaya Kumar1, Adam Williams2.   

Abstract

Long non-coding RNAs (lncRNAs) are potent regulators of immune cell development and function. Their implication in multiple immune-mediated disorders highlights lncRNAs as exciting biomarkers and potential drug targets. Recent technological innovations in oligo-based therapeutics, development of RNA-targeting small molecules, and CRISPR-based approaches, position RNA as the next therapeutic frontier. Here, we review the latest advances made toward understanding the role of lncRNAs in human immunological disorders and further discuss RNA-targeting approaches that could be potentially exploited to manipulate lncRNA function as a clinical intervention.
Copyright © 2020 Elsevier B.V. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2020        PMID： 32058929      PMCID： PMC7150622          DOI： 10.1016/j.intimp.2020.106279

Source DB:  PubMed          Journal:  Int Immunopharmacol        ISSN： 1567-5769            Impact factor:   4.932


  129 in total

1.  Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.

Authors:  Walter K Mowel; Sam J McCright; Jonathan J Kotzin; Magalie A Collet; Asli Uyar; Xin Chen; Alexandra DeLaney; Sean P Spencer; Anthony T Virtue; EnJun Yang; Alejandro Villarino; Makoto Kurachi; Margaret C Dunagin; Gretchen Harms Pritchard; Judith Stein; Cynthia Hughes; Diogo Fonseca-Pereira; Henrique Veiga-Fernandes; Arjun Raj; Taku Kambayashi; Igor E Brodsky; John J O'Shea; E John Wherry; Loyal A Goff; John L Rinn; Adam Williams; Richard A Flavell; Jorge Henao-Mejia
Journal:  Immunity       Date:  2017-09-19       Impact factor: 31.745

2.  Targeted delivery of RNAi therapeutics with endogenous and exogenous ligand-based mechanisms.

Authors:  Akin Akinc; William Querbes; Soma De; June Qin; Maria Frank-Kamenetsky; K Narayanannair Jayaprakash; Muthusamy Jayaraman; Kallanthottathil G Rajeev; William L Cantley; J Robert Dorkin; James S Butler; Liuliang Qin; Timothy Racie; Andrew Sprague; Eugenio Fava; Anja Zeigerer; Michael J Hope; Marino Zerial; Dinah W Y Sah; Kevin Fitzgerald; Mark A Tracy; Muthiah Manoharan; Victor Koteliansky; Antonin de Fougerolles; Martin A Maier
Journal:  Mol Ther       Date:  2010-05-11       Impact factor: 11.454

Review 3.  Origins and Mechanisms of miRNAs and siRNAs.

Authors:  Richard W Carthew; Erik J Sontheimer
Journal:  Cell       Date:  2009-02-20       Impact factor: 41.582

Review 4.  CD8 T cells and Mycobacterium tuberculosis infection.

Authors:  Philana Ling Lin; JoAnne L Flynn
Journal:  Semin Immunopathol       Date:  2015-04-28       Impact factor: 9.623

5.  Dynamic PolyConjugates for targeted in vivo delivery of siRNA to hepatocytes.

Authors:  David B Rozema; David L Lewis; Darren H Wakefield; So C Wong; Jason J Klein; Paula L Roesch; Stephanie L Bertin; Tom W Reppen; Qili Chu; Andrei V Blokhin; James E Hagstrom; Jon A Wolff
Journal:  Proc Natl Acad Sci U S A       Date:  2007-07-24       Impact factor: 11.205

6.  A long noncoding RNA associated with susceptibility to celiac disease.

Authors:  Ainara Castellanos-Rubio; Nora Fernandez-Jimenez; Radomir Kratchmarov; Xiaobing Luo; Govind Bhagat; Peter H R Green; Robert Schneider; Megerditch Kiledjian; Jose Ramon Bilbao; Sankar Ghosh
Journal:  Science       Date:  2016-04-01       Impact factor: 47.728

7.  Anti-interleukin-5 (mepolizumab) therapy for hypereosinophilic syndromes.

Authors:  Jennifer K Garrett; Sean C Jameson; Blythe Thomson; Margaret H Collins; Lynne E Wagoner; Debbie K Freese; Lisa A Beck; Joshua A Boyce; Alexandra H Filipovich; Joyce M Villanueva; Steven A Sutton; Amal H Assa'ad; Marc E Rothenberg
Journal:  J Allergy Clin Immunol       Date:  2003-12-12       Impact factor: 10.793

8.  Pervasive transcription of the human genome produces thousands of previously unidentified long intergenic noncoding RNAs.

Authors:  Matthew J Hangauer; Ian W Vaughn; Michael T McManus
Journal:  PLoS Genet       Date:  2013-06-20       Impact factor: 5.917

9.  The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA.

Authors:  Timothy A Vickers; Stanley T Crooke
Journal:  Nucleic Acids Res       Date:  2015-09-17       Impact factor: 16.971

10.  Long non-coding RNA NKILA inhibits migration and invasion of tongue squamous cell carcinoma cells via suppressing epithelial-mesenchymal transition.

Authors:  Wei Huang; Xiuying Cui; Jianing Chen; Yuhuan Feng; Erwei Song; Jinsong Li; Yujie Liu
Journal:  Oncotarget       Date:  2016-09-20
View more
  8 in total

1.  Bronchial epithelium epithelial-mesenchymal plasticity forms aberrant basaloid-like cells in vitro.

Authors:  Dinesh Babu Uthaya Kumar; Efthymios Motakis; Marina Yurieva; Vivek Kohar; Jan Martinek; Te-Chia Wu; Johad Khoury; Jessica Grassmann; Mingyang Lu; Karolina Palucka; Naftali Kaminski; Jonathan L Koff; Adam Williams
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2022-04-19       Impact factor: 6.011

2.  lncRNA expression profiles related to apoptosis and autophagy in peripheral blood mononuclear cells of patients with rheumatoid arthritis.

Authors:  Jianting Wen; Jian Liu; Hui Jiang; Lei Wan; Ling Xin; Yue Sun; Pingheng Zhang; Yanqiu Sun; Ying Zhang; Xinlei Du; Xin Wang; Jie Wang
Journal:  FEBS Open Bio       Date:  2020-07-22       Impact factor: 2.693

3.  Identification of Differentially Expressed lncRNAs and mRNAs in Children with Acquired Aplastic Anemia by RNA Sequencing.

Authors:  Shuanglong Lu; Xiaoxiao Song; Jing Chen; Xiaohong Qiao
Journal:  Biomed Res Int       Date:  2020-06-28       Impact factor: 3.411

Review 4.  Role of Long Non-Coding RNAs in the Chemoresistance of Gastric Cancer: A Systematic Review.

Authors:  Zonglin Li; Muhan Lü; Yejiang Zhou; Linxia Xu; Yifan Jiang; Yi Liu; Xin Li; Min Song
Journal:  Onco Targets Ther       Date:  2021-01-18       Impact factor: 4.147

5.  Predicting prognosis and immunotherapy response among colorectal cancer patients based on a tumor immune microenvironment-related lncRNA signature.

Authors:  Chuling Hu; Du Cai; Min-Er Zhong; Dejun Fan; Cheng-Hang Li; Min-Yi Lv; Ze-Ping Huang; Wei Wang; Xiao-Jian Wu; Feng Gao
Journal:  Front Genet       Date:  2022-09-07       Impact factor: 4.772

Review 6.  Long non-coding RNAs mediate cerebral vascular pathologies after CNS injuries.

Authors:  Mengqi Zhang; Milton H Hamblin; Ke-Jie Yin
Journal:  Neurochem Int       Date:  2021-06-18       Impact factor: 4.297

7.  LINC01123 promotes immune escape by sponging miR-214-3p to regulate B7-H3 in head and neck squamous-cell carcinoma.

Authors:  Huan Li; Zihui Yang; Xiangming Yang; Fengrui Zhang; Jun Wang; Zhongming Wu; Chaojie Wanyan; Qingzhe Meng; Wanpeng Gao; Xinjie Yang; Jianhua Wei
Journal:  Cell Death Dis       Date:  2022-02-03       Impact factor: 8.469

8.  LINC00942 Promotes Tumor Proliferation and Metastasis in Lung Adenocarcinoma via FZD1 Upregulation.

Authors:  Ronghua Wang; Xiuyun Wang; Jingtao Zhang; Yanpei Liu
Journal:  Technol Cancer Res Treat       Date:  2021 Jan-Dec
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.