| Literature DB >> 32058913 |
Shatavisha Dasgupta1, Patricia C Ewing-Graham2, Sigrid M A Swagemakers3, Peter J van der Spek4, Helena C van Doorn5, Vincent Noordhoek Hegt6, Senada Koljenović7, Folkert J van Kemenade8.
Abstract
The precursor lesion of vulvar squamous cell carcinoma (VSCC), namely vulvar intraepithelial neoplasia (VIN), is classified as: human papillomavirus (HPV)-related high grade squamous intraepithelial lesion (HSIL), and HPV-independent differentiated VIN (dVIN). Traditionally, histology and immunohistochemistry (IHC) have been the basis of diagnosis and classification of VIN. HSIL shows conspicuous histological atypia, and positivity on p16-IHC, whereas dVIN shows less obvious histological atypia, and overexpression or null-pattern on p53-IHC. For both types of VIN, other diagnostic immunohistochemical markers have also been evaluated. Molecular characterization of VIN has been attempted in few recent studies, and novel genotypic subtypes of HPV-independent VSCC and VIN have been identified. This systematic review appraises the VSCC precursors identified so far, focusing on histology and biomarkers (immunohistochemical and molecular). To gain further insights into the carcinogenesis and to identify additional potential biomarkers, gene expression omnibus (GEO) datasets on VSCC were analyzed; the results are presented.Entities:
Keywords: Biomarker; Expression array; Histology; Immunohistochemistry; Precursor lesion; Squamous cell carcinoma; Systematic review; Vulva; Vulvar intraepithelial neoplasia
Year: 2020 PMID： 32058913 DOI： 10.1016/j.critrevonc.2020.102866
Source DB: PubMed Journal: Crit Rev Oncol Hematol ISSN： 1040-8428 Impact factor: 6.312