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Literature DB >> 32058297

TRPM2, linking oxidative stress and Ca²⁺ permeation to NLRP3 inflammasome activation.

Abstract

The NLRP3 inflammasome is an innate immune platform that senses various pathogens and sterile insults. NLRP3 stimulation leads to activation of caspase-1, the secretion of pro-inflammatory cytokines and an inflammatory cell death called pyroptosis. Effectors of the NLRP3 inflammasome efficiently drive an immune response, not only providing protection in physiological settings but also promoting pathology when over activated. Generation of reactive oxygen species (ROS) and intracellular calcium mobilization can activate the NLRP3 inflammasome. Recent studies suggest that TRPM2 is a calcium-permeable cation channel mediating ROS-dependent NLRP3 activation. Here, we review the role of TRPM2 in NLRP3 inflammasome activation and provide an update on new functional and structural discoveries. Understanding the molecular mechanism of TRPM2 dependent NLRP3 inflammasome activation will shed lights on this complex pathway and help the developing of therapeutic strategies.

Entities: Chemical Disease Gene Species

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Year: 2020 PMID： 32058297 PMCID： PMC7533107 DOI： 10.1016/j.coi.2020.01.005

Source DB: PubMed Journal: Curr Opin Immunol ISSN： 0952-7915 Impact factor: 7.486

37 in total

Review 1. New insights into TRP channels: Interaction with pattern recognition receptors.

Authors: Huirong Han; Fan Yi
Journal: Channels (Austin) Date: 2013-12-03 Impact factor: 2.581

2. K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.

Authors: Raúl Muñoz-Planillo; Peter Kuffa; Giovanny Martínez-Colón; Brenna L Smith; Thekkelnaycke M Rajendiran; Gabriel Núñez
Journal: Immunity Date: 2013-06-27 Impact factor: 31.745

Review 3. Role of interleukins in obesity: implications for metabolic disease.

Authors: Mark A Febbraio
Journal: Trends Endocrinol Metab Date: 2014-03-31 Impact factor: 12.015

Review 4. Intracellular Ca²⁺ Sensing: Its Role in Calcium Homeostasis and Signaling.

Authors: Rafaela Bagur; György Hajnóczky
Journal: Mol Cell Date: 2017-06-15 Impact factor: 17.970

5. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.

Authors: Fabio Martinon; Laetitia Agostini; Etienne Meylan; Jürg Tschopp
Journal: Curr Biol Date: 2004-11-09 Impact factor: 10.834

6. Gout-associated uric acid crystals activate the NALP3 inflammasome.

Authors: Fabio Martinon; Virginie Pétrilli; Annick Mayor; Aubry Tardivel; Jürg Tschopp
Journal: Nature Date: 2006-01-11 Impact factor: 49.962

7. The crystal structure and mutational analysis of human NUDT9.

Authors: Betty W Shen; Anne Laure Perraud; Andrew Scharenberg; Barry L Stoddard
Journal: J Mol Biol Date: 2003-09-12 Impact factor: 5.469

8. Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors.

Authors: Manuela Rossol; Matthias Pierer; Nora Raulien; Dagmar Quandt; Undine Meusch; Kathrin Rothe; Kristin Schubert; Torsten Schöneberg; Michael Schaefer; Ute Krügel; Sanela Smajilovic; Hans Bräuner-Osborne; Christoph Baerwald; Ulf Wagner
Journal: Nat Commun Date: 2012 Impact factor: 14.919

9. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance.

Authors: Bolormaa Vandanmagsar; Yun-Hee Youm; Anthony Ravussin; Jose E Galgani; Krisztian Stadler; Randall L Mynatt; Eric Ravussin; Jacqueline M Stephens; Vishwa Deep Dixit
Journal: Nat Med Date: 2011-01-09 Impact factor: 53.440

10. TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells.

Authors: Hisa Hui Ling Tseng; Chi Teng Vong; Yiu Wa Kwan; Simon Ming-Yuen Lee; Maggie Pui Man Hoi
Journal: Sci Rep Date: 2016-10-12 Impact factor: 4.379

14 in total

1. The Antibody Receptor Fc Gamma Receptor IIIb Induces Calcium Entry via Transient Receptor Potential Melastatin 2 in Human Neutrophils.

Authors: Omar Rafael Alemán; Nancy Mora; Carlos Rosales
Journal: Front Immunol Date: 2021-05-13 Impact factor: 7.561

Review 2. Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome.

Authors: Roberto De Luca; Paul J Davis; Hung-Yun Lin; Fabio Gionfra; Zulema A Percario; Elisabetta Affabris; Jens Z Pedersen; Cinzia Marchese; Pankaj Trivedi; Eleni Anastasiadou; Roberto Negro; Sandra Incerpi
Journal: Front Cell Dev Biol Date: 2021-01-21

3. Insight Into Inflammasome Signaling: Implications for Toxoplasma gondii Infection.

Authors: Yang Wang; Jinjin Zhu; Yuanyuan Cao; Jilong Shen; Li Yu
Journal: Front Immunol Date: 2020-12-16 Impact factor: 7.561

Review 4. An update on the regulatory mechanisms of NLRP3 inflammasome activation.

Authors: Seungwha Paik; Jin Kyung Kim; Prashanta Silwal; Chihiro Sasakawa; Eun-Kyeong Jo
Journal: Cell Mol Immunol Date: 2021-04-13 Impact factor: 11.530

5. Methamphetamine and HIV-Tat Protein Synergistically Induce Oxidative Stress and Blood-Brain Barrier Damage via Transient Receptor Potential Melastatin 2 Channel.

Authors: Jian Huang; Ruilin Zhang; Shangwen Wang; Dongxian Zhang; Chi-Kwan Leung; Genmeng Yang; Yuanyuan Li; Liu Liu; Yue Xu; Shucheng Lin; Chan Wang; Xiaofeng Zeng; Juan Li
Journal: Front Pharmacol Date: 2021-03-17 Impact factor: 5.810

6. Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients.

Authors: Iago C Schultz; Ana Paula S Bertoni; Márcia R Wink
Journal: J Mol Med (Berl) Date: 2022-01-29 Impact factor: 4.599

Review 10. Synergistic Impairment of the Neurovascular Unit by HIV-1 Infection and Methamphetamine Use: Implications for HIV-1-Associated Neurocognitive Disorders.

Authors: Nikolai Fattakhov; Silvia Torices; Michael Stangis; Minseon Park; Michal Toborek
Journal: Viruses Date: 2021-09-21 Impact factor: 5.048

TRPM2, linking oxidative stress and Ca²⁺ permeation to NLRP3 inflammasome activation.

Review 1. New insights into TRP channels: Interaction with pattern recognition receptors.

2. K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.

Review 3. Role of interleukins in obesity: implications for metabolic disease.

Review 4. Intracellular Ca²⁺ Sensing: Its Role in Calcium Homeostasis and Signaling.

5. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome.

6. Gout-associated uric acid crystals activate the NALP3 inflammasome.

7. The crystal structure and mutational analysis of human NUDT9.

8. Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors.

9. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance.

10. TRPM2 regulates TXNIP-mediated NLRP3 inflammasome activation via interaction with p47 phox under high glucose in human monocytic cells.

1. The Antibody Receptor Fc Gamma Receptor IIIb Induces Calcium Entry via Transient Receptor Potential Melastatin 2 in Human Neutrophils.

Review 2. Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome.

3. Insight Into Inflammasome Signaling: Implications for Toxoplasma gondii Infection.

Review 4. An update on the regulatory mechanisms of NLRP3 inflammasome activation.

5. Methamphetamine and HIV-Tat Protein Synergistically Induce Oxidative Stress and Blood-Brain Barrier Damage via Transient Receptor Potential Melastatin 2 Channel.

6. Purinergic signaling elements are correlated with coagulation players in peripheral blood and leukocyte samples from COVID-19 patients.

Review 7. Redox control in the pathophysiology of influenza virus infection.

Review 8. Structure-Function Relationship of TRPM2: Recent Advances, Contradictions, and Open Questions.

9. The role of NLRP3 inflammasome for microglial response to peripheral inflammation.

Review 10. Synergistic Impairment of the Neurovascular Unit by HIV-1 Infection and Methamphetamine Use: Implications for HIV-1-Associated Neurocognitive Disorders.

Review 1. New insights into TRP channels: Interaction with pattern recognition receptors.

Review 3. Role of interleukins in obesity: implications for metabolic disease.

Review 4. Intracellular Ca2+ Sensing: Its Role in Calcium Homeostasis and Signaling.

Review 2. Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome.

Review 4. An update on the regulatory mechanisms of NLRP3 inflammasome activation.

Review 7. Redox control in the pathophysiology of influenza virus infection.

Review 8. Structure-Function Relationship of TRPM2: Recent Advances, Contradictions, and Open Questions.

Review 10. Synergistic Impairment of the Neurovascular Unit by HIV-1 Infection and Methamphetamine Use: Implications for HIV-1-Associated Neurocognitive Disorders.

Review 4. Intracellular Ca²⁺ Sensing: Its Role in Calcium Homeostasis and Signaling.