Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The role of the dystrophin glycoprotein complex on the neuromuscular system.

Literature DB >> 32057921

The role of the dystrophin glycoprotein complex on the neuromuscular system.

Abstract

The Dystrophin Glycoprotein Complex (DGC) is a large multi-protein complex that links cytoskeleton actin to the extracellular matrix. This complex is critical in maintaining the structural integrity of muscle fibers and the stability of the neuromuscular synapse. The DGC consists of dystrophin and its utrophin homolog, as well as dystroglycans, sarcoglycans, sarcospan, syntrophins, and dystrobrevins. Deficiencies in DGC proteins result in several forms of muscular dystrophy with varying symptoms and degrees of severity in addition to structurally abnormal neuromuscular junctions (NMJs). This mini-review highlights current knowledge regarding the role of the DGC on the molecular dynamics of acetylcholine receptors (AChRs) as it relates to the formation and maintenance of the mammalian NMJ.

Entities: Chemical

Keywords: AChR dynamics; Dystrophin glycoprotein complex; Neuromuscular junction

Mesh：

Substances：

Year: 2020 PMID： 32057921 PMCID： PMC8792866 DOI： 10.1016/j.neulet.2020.134833

Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046

94 in total

1. The absence of dystrophin rather than muscle degeneration causes acetylcholine receptor cluster defects in dystrophic muscle.

Authors: Jie Kong; Liqing Yang; Qiuling Li; Jiqing Cao; Juan Yang; Fei Chen; Yanyun Wang; Cheng Zhang
Journal: Neuroreport Date: 2012-01-25 Impact factor: 1.837

2. Chimaeric mice deficient in dystroglycans develop muscular dystrophy and have disrupted myoneural synapses.

Authors: P D Côté; H Moukhles; M Lindenbaum; S Carbonetto
Journal: Nat Genet Date: 1999-11 Impact factor: 38.330

3. Disruption of the beta-sarcoglycan gene reveals pathogenetic complexity of limb-girdle muscular dystrophy type 2E.

Authors: M Durbeej; R D Cohn; R F Hrstka; S A Moore; V Allamand; B L Davidson; R A Williamson; K P Campbell
Journal: Mol Cell Date: 2000-01 Impact factor: 17.970

4. Interactions of the rapsyn RING-H2 domain with dystroglycan.

Authors: M Bartoli; M K Ramarao; J B Cohen
Journal: J Biol Chem Date: 2001-05-07 Impact factor: 5.157

5. The molecular basis of muscular dystrophy in the mdx mouse: a point mutation.

Authors: P Sicinski; Y Geng; A S Ryder-Cook; E A Barnard; M G Darlison; P J Barnard
Journal: Science Date: 1989-06-30 Impact factor: 47.728

Review 6. The dystrophin glycoprotein complex: signaling strength and integrity for the sarcolemma.

Authors: Karen A Lapidos; Rahul Kakkar; Elizabeth M McNally
Journal: Circ Res Date: 2004-04-30 Impact factor: 17.367

7. Agrin mediates cell contact-induced acetylcholine receptor clustering.

Authors: J T Campanelli; W Hoch; F Rupp; T Kreiner; R H Scheller
Journal: Cell Date: 1991-11-29 Impact factor: 41.582

8. Muscle regeneration after imposed injury is better in younger than older mdx dystrophic mice.

Authors: J M Zacharias; J E Anderson
Journal: J Neurol Sci Date: 1991-08 Impact factor: 3.181

9. Identification of the Syrian hamster cardiomyopathy gene.

Authors: V Nigro; Y Okazaki; A Belsito; G Piluso; Y Matsuda; L Politano; G Nigro; C Ventura; C Abbondanza; A M Molinari; D Acampora; M Nishimura; Y Hayashizaki; G A Puca
Journal: Hum Mol Genet Date: 1997-04 Impact factor: 6.150

10. The sparing of extraocular muscle in dystrophinopathy is lost in mice lacking utrophin and dystrophin.

Authors: J D Porter; J A Rafael; R J Ragusa; J K Brueckner; J I Trickett; K E Davies
Journal: J Cell Sci Date: 1998-07 Impact factor: 5.285

19 in total

1. Mouse Models of Muscle Fibrosis.

Authors: Antonio L Serrano; Pura Muñoz-Cánoves
Journal: Methods Mol Biol Date: 2021

2. Simple Methods for Permanent or Transient Denervation in Mouse Sciatic Nerve Injury Models.

Authors: Alexis Osseni; Jean-Luc Thomas; Alireza Ghasemizadeh; Laurent Schaeffer; Vincent Gache
Journal: Bio Protoc Date: 2022-06-05

3. Distinct roles of the dystrophin-glycoprotein complex: α-dystrobrevin and α-syntrophin in the maintenance of the postsynaptic apparatus of the neuromuscular synapse.

Authors: Isabel Martinez-Pena Y Valenzuela; Po-Ju Chen; Joseph Barden; Olivia Kosloski; Mohammed Akaaboune
Journal: Hum Mol Genet Date: 2022-07-21 Impact factor: 5.121

4. Phosphorylation of α-dystrobrevin is essential for αkap accumulation and acetylcholine receptor stability.

Authors: Po-Ju Chen; Diego Zelada; Dina Cheryne Belhasan; Mohammed Akaaboune
Journal: J Biol Chem Date: 2020-06-12 Impact factor: 5.157

Review 5. Alterations of neuromuscular junctions in Duchenne muscular dystrophy.

Authors: Richard M Lovering; Shama R Iyer; Benjamin Edwards; Kay E Davies
Journal: Neurosci Lett Date: 2020-08-17 Impact factor: 3.046

Review 6. A Role for Caveolin-3 in the Pathogenesis of Muscular Dystrophies.

Authors: Bhola Shankar Pradhan; Tomasz J Prószyński
Journal: Int J Mol Sci Date: 2020-11-19 Impact factor: 5.923

Review 7. Recent insights into neuromuscular junction biology in Duchenne muscular dystrophy: Impacts, challenges, and opportunities.

Authors: Sean Y Ng; Vladimir Ljubicic
Journal: EBioMedicine Date: 2020-10-08 Impact factor: 8.143

Review 8. Secreted Signaling Molecules at the Neuromuscular Junction in Physiology and Pathology.

Authors: Bisei Ohkawara; Mikako Ito; Kinji Ohno
Journal: Int J Mol Sci Date: 2021-02-28 Impact factor: 5.923

Review 9. Multiple MuSK signaling pathways and the aging neuromuscular junction.

Authors: Lauren A Fish; Justin R Fallon
Journal: Neurosci Lett Date: 2020-04-28 Impact factor: 3.046

10. Myasthenia Gravis: From the Viewpoint of Pathogenicity Focusing on Acetylcholine Receptor Clustering, Trans-Synaptic Homeostasis and Synaptic Stability.

Authors: Masaharu Takamori
Journal: Front Mol Neurosci Date: 2020-05-28 Impact factor: 5.639