Literature DB >> 32057477

Early detection of ventricular arrhythmias in adults with congenital heart disease using an insertable cardiac monitor (EDVA-CHD study).

Rafi Sakhi1, Robert M Kauling1, Dominic A Theuns1, Tamas Szili-Torok1, Rohit E Bhagwandien1, Annemien E van den Bosch1, Judith A A E Cuypers1, Jolien W Roos-Hesselink1, Sing-Chien Yap2.   

Abstract

BACKGROUND: Sudden cardiac death (SCD) due to ventricular arrhythmias (VA) is an important mode of death in adults with congenital heart disease (CHD). Risk stratification is difficult in this heterogeneous population. Insertable cardiac monitors (ICM) may be useful for risk stratification. The purpose of the present study was to evaluate the use of ICM for the detection of VA in adults with CHD.
METHODS: In this prospective single-center observational study we included consecutive adults with CHD deemed at risk of VA who received an ICM between March 2013 and February 2019. The decision to implant an ICM was made in a Heart Team consisting of a cardiac electrophysiologist and a cardiologist specialized in CHD.
RESULTS: A total of 30 patients (mean age, 38 ± 15 years; 50% male) received an ICM. During a median follow-up of 16 months, 8 patients (27%) had documented nonsustained VA. Of these 8 patients, 3 (10%) received a prophylactic ICD. Furthermore, ICM-detected arrhythmias were present in 22 patients (73%) leading to a change in clinical management in 16 patients (53%). Besides the patients receiving an ICD, 10 patients (33%) had a change in their antiarrhythmic drugs, 6 patients (20%) underwent an electrophysiology study, and 1 patient (3%) received a pacemaker.
CONCLUSIONS: The detection of VA by the ICM contributed to the clinical decision to implant a prophylactic ICD. Furthermore, ICM-detected arrhythmias led to important changes in the clinical management. Therefore, long-term arrhythmia monitoring by an ICM seems valuable for risk stratification in adults with CHD.
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Congenital heart disease; Implantable loop recorder; Risk stratification; Sudden cardiac death; Ventricular arrhythmias

Mesh:

Year:  2020        PMID: 32057477     DOI: 10.1016/j.ijcard.2020.02.009

Source DB:  PubMed          Journal:  Int J Cardiol        ISSN: 0167-5273            Impact factor:   4.164


  6 in total

1.  Implantable loop recorder for monitoring patients with congenital heart disease.

Authors:  Michael Huntgeburth; Christopher Hohmann; Harald Kaemmerer; Christof Kolb; Peter Ewert; Sebastian Freilinger; Nicole Nagdyman; Rhoia Neidenbach; Lars Pieper; Felix Pieringer; Carsten Lennerz
Journal:  Cardiovasc Diagn Ther       Date:  2021-12

2.  SOX7 loss-of-function variation as a cause of familial congenital heart disease.

Authors:  Ri-Tai Huang; Yu-Han Guo; Chen-Xi Yang; Jia-Ning Gu; Xing-Biao Qiu; Hong-Yu Shi; Ying-Jia Xu; Song Xue; Yi-Qing Yang
Journal:  Am J Transl Res       Date:  2022-03-15       Impact factor: 4.060

3.  Circular RNA hsa_circ_105039 promotes cardiomyocyte differentiation by sponging miR‑17 to regulate cyclinD2 expression.

Authors:  Boshi Yu; Mengmeng Li; Shu Ping Han; Zhangbin Yu; Jingai Zhu
Journal:  Mol Med Rep       Date:  2021-10-19       Impact factor: 2.952

4.  A novel KLF13 mutation underlying congenital patent ductus arteriosus and ventricular septal defect, as well as bicuspid aortic valve.

Authors:  Pradhan Abhinav; Gao-Feng Zhang; Cui-Mei Zhao; Ying-Jia Xu; Juan Wang; Yi-Qing Yang
Journal:  Exp Ther Med       Date:  2022-03-01       Impact factor: 2.447

5.  Identification of SOX18 as a New Gene Predisposing to Congenital Heart Disease.

Authors:  Hong-Yu Shi; Meng-Shi Xie; Chen-Xi Yang; Ri-Tai Huang; Song Xue; Xing-Yuan Liu; Ying-Jia Xu; Yi-Qing Yang
Journal:  Diagnostics (Basel)       Date:  2022-08-08

6.  Implantable loop recorders in patients with heart disease: comparison between patients with and without syncope.

Authors:  Amira Assaf; Rafi Sakhi; Michelle Michels; Jolien W Roos-Hesselink; Judith M A Verhagen; Rohit E Bhagwandien; Tamas Szili-Torok; Dominic Theuns; Sing-Chien Yap
Journal:  Open Heart       Date:  2021-08
  6 in total

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