| Literature DB >> 32056430 |
Sugyeom Kim1, Yu Li1, Lin Lin1, Peyton R Sayasith1, Ariel T Tarr1, Eric B Wright, Sharia Yasmin, Deborah A Lannigan, George A O'Doherty1.
Abstract
The synthesis of two series of five kaempfer-3-ols was described. The first set all have a C-3 hydroxyl group and the second has a carboxymethoxy ether at the C-3 position. Both series have variable substitution at the C-4' position (i.e., OH, Cl, F, H, OMe). Both kaempferols and carboxymethoxy ethers were evaluated for their ability to inhibit ribosomal s6 kinase (RSK) activity and cancer cell proliferation.Entities:
Mesh：
Year: 2020 PMID： 32056430 PMCID： PMC7285650 DOI： 10.1021/acs.joc.9b03461
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354