Jung Hun Kang1, Su-Jin Koh2, So Yeon Oh3, Rock Bum Kim4, Seong Hoon Shin5, Yun-Gyoo Lee6, Bong-Seog Kim7, Hun Mo Ryoo8, So Young Yoon9, Joung Soon Jang10, Ho-Suk Oh11, Young Jin Choi12, Moon Hee Lee13, Kyung-Hee Lee14. 1. Department of Internal Medicine, Gyeongsang National University, Jinju, Republic of Korea. 2. Department of Hematology and Oncology, Ulsan University Hospital, Ulsan University College of Medicine, Ulsan, Republic of Korea. 3. Department of Internal medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea. 4. Department of Preventive Medicine, Regional Cardiocerebrovascular Disease Center, Gyeongsang National University Hospital, Jinju, Republic of Korea. 5. Department of Internal Medicine, Division of Hemato-Oncology, Kosin University Gospel Hospital, Busan, Republic of Korea. 6. Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. 7. Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Republic of Korea. 8. Department of Internal Medicine, School of Medicine, Catholic University of Daegu, Daegu, Republic of Korea. 9. Department of Internal Medicine, Konkuk University School of Medicine, Seoul, South Korea. 10. Department of Internal Medicine, Chung-Ang University, Seoul, Republic of Korea. 11. Department of Internal Medicine, Gangneung Asan Hospital, University of Ulsan College of Medicine, Gangneung, Republic of Korea. 12. Department of Internal Medicine, School of Medicine, Pusan National University, Busan, Republic of Korea. 13. Department of Internal Medicine, Inha University Hospital, College of Medicine, Inha University, Incheon, Republic of Korea. 14. Department of Internal Medicine, Yeungnam University, Daegu, Republic of Korea. lkhee@med.yu.ac.kr.
Abstract
PURPOSE: To investigate the association between quality of life (QOL) and breakthrough cancer pain (BTCP) intensity in patients who met the commonly accepted definition of BTCP. METHODS: This study was a subset analysis of a South Korean multicenter, non-interventional, cross-sectional, nationwide survey. Participants were recruited from March 2016 to December 2017. BTCP was defined as a controlled background pain of less than a numeric rating scale (NRS) of 3 and any flare-up pain intensity. Pain intensity data were collected using the Brief Pain Inventory (BPI), which includes an interference assessment of the affective and physical domains. Patients were categorized by BTCP intensity into mild (NRS 1-3), moderate (4-6), and severe (7-10) groups. RESULTS: Of the 969 screened patients with cancer, 679 had ≤ NRS 3 background pain, of whom 438 completed the BPI. Of these 438 patients, 40, 204, and 194 were in the mild, moderate, and severe BTCP groups, respectively. The median NRS of BTCP was 6.0 (interquartile range = 5.0-8.0). Patients with moderate-severe BTCP had significantly higher interference with daily functioning (IDF) scores than did mild BTCP patients (3.3 vs. 5.7; p < 0.01). Both domains of IDF were significantly hampered proportionally by increased BTCP intensity (p < 0.001). The median total IDF scores of the no, moderate, and severe BTCP groups were 3.3, 5.0, and 6.9, respectively. Furthermore, IDF depended on BTCP intensity, duration, and frequency (p < 0.01) but not on pain type and cause. CONCLUSION: An increase in BTCP intensity is likely to result in IDF, regardless of the cause or type of BTCP.
PURPOSE: To investigate the association between quality of life (QOL) and breakthrough cancer pain (BTCP) intensity in patients who met the commonly accepted definition of BTCP. METHODS: This study was a subset analysis of a South Korean multicenter, non-interventional, cross-sectional, nationwide survey. Participants were recruited from March 2016 to December 2017. BTCP was defined as a controlled background pain of less than a numeric rating scale (NRS) of 3 and any flare-up pain intensity. Pain intensity data were collected using the Brief Pain Inventory (BPI), which includes an interference assessment of the affective and physical domains. Patients were categorized by BTCP intensity into mild (NRS 1-3), moderate (4-6), and severe (7-10) groups. RESULTS: Of the 969 screened patients with cancer, 679 had ≤ NRS 3 background pain, of whom 438 completed the BPI. Of these 438 patients, 40, 204, and 194 were in the mild, moderate, and severe BTCP groups, respectively. The median NRS of BTCP was 6.0 (interquartile range = 5.0-8.0). Patients with moderate-severe BTCP had significantly higher interference with daily functioning (IDF) scores than did mild BTCPpatients (3.3 vs. 5.7; p < 0.01). Both domains of IDF were significantly hampered proportionally by increased BTCP intensity (p < 0.001). The median total IDF scores of the no, moderate, and severe BTCP groups were 3.3, 5.0, and 6.9, respectively. Furthermore, IDF depended on BTCP intensity, duration, and frequency (p < 0.01) but not on pain type and cause. CONCLUSION: An increase in BTCP intensity is likely to result in IDF, regardless of the cause or type of BTCP.
Entities:
Keywords:
Breakthrough cancer pain; Brief pain inventory; Interference with daily functioning; Quality of life
Authors: Gillian Bedard; Andrew Davies; Rachel McDonald; Philippa Hawley; Alison Buchanan; Marko Popovic; Erin Wong; Edward Chow Journal: Support Care Cancer Date: 2014-09-06 Impact factor: 3.603
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