Pauline Vasseur1,2, Emmanuelle Dugelay3, Robert Benamouzig4, Guillaume Savoye5, Annaïg Lan6, Bernard Srour1, Serge Hercberg1,2, Mathilde Touvier1, Jean-Pierre Hugot3,7, Chantal Julia1,2, Camille Buscail1,2. 1. Equipe de Recherche en Épidémiologie Nutritionnelle (EREN), Université Paris 13, Inserm U1153, Inra U1125, Cnam, CRESS, Bobigny, France. 2. Département de Santé Publique, Hôpital Avicenne (APHP), Bobigny, France. 3. Service de Gastroentérologie et Nutrition Pédiatrique, Hôpital Robert Debré (APHP), Paris, France. 4. Service de Gastroentérologie, Hôpital Avicenne (APHP), Bobigny, France. 5. Service de Gastroentérologie, Hôpital Charles Nicolle, Rouen, France. 6. UMR PNCA, AgroParisTech, INRA, Université Paris-Saclay, Paris, France. 7. Centre de Recherche sur l'Inflammation, UMR1149 INSERM et Université de Paris, Paris, France.
Abstract
BACKGROUND: The incidence of inflammatory bowel diseases (IBDs) tended to increase for several decades. Diet is suspected to be a major determinant of the occurrence of these diseases. This prospective study aimed to assess the associations among occurrence of IBD, dietary patterns, and ultra-processed food in the French NutriNet-Santé cohort. METHODS: Participants of the NutriNet-Santé cohort who completed at least three 24-hour dietary records were included. Incident IBD cases were identified from 3 questionnaires and confirmed by phone or email interview. Major dietary patterns (DPs) were computed using a principal component analysis (PCA) based on 29 food groups' consumption, whereas proportions of ultra-processed foods (UPFs) were obtained using the NOVA classification. Multivariable Poisson models were performed to evaluate associations among DP quintiles, UPF proportion (UPFp) in the diet, and incident IBD. RESULTS: A total of 105,832 participants were included, contributing 238,924 person-years in a mean follow-up of 2.3 ± 2.2 years. Among them, 75 participants reported an incident IBD. Three major DPs were retained: "healthy," "traditional," and "western." No significant association was found for DPs and UPFp after adjustments for covariates. CONCLUSIONS: In this study, neither DPs nor UPF proportion in the diet were significantly associated with the risk of incident IBD after adjustments for covariates. Further studies are needed to investigate the long-term association between diet and IBD.
BACKGROUND: The incidence of inflammatory bowel diseases (IBDs) tended to increase for several decades. Diet is suspected to be a major determinant of the occurrence of these diseases. This prospective study aimed to assess the associations among occurrence of IBD, dietary patterns, and ultra-processed food in the French NutriNet-Santé cohort. METHODS:Participants of the NutriNet-Santé cohort who completed at least three 24-hour dietary records were included. Incident IBD cases were identified from 3 questionnaires and confirmed by phone or email interview. Major dietary patterns (DPs) were computed using a principal component analysis (PCA) based on 29 food groups' consumption, whereas proportions of ultra-processed foods (UPFs) were obtained using the NOVA classification. Multivariable Poisson models were performed to evaluate associations among DP quintiles, UPF proportion (UPFp) in the diet, and incident IBD. RESULTS: A total of 105,832 participants were included, contributing 238,924 person-years in a mean follow-up of 2.3 ± 2.2 years. Among them, 75 participants reported an incident IBD. Three major DPs were retained: "healthy," "traditional," and "western." No significant association was found for DPs and UPFp after adjustments for covariates. CONCLUSIONS: In this study, neither DPs nor UPF proportion in the diet were significantly associated with the risk of incident IBD after adjustments for covariates. Further studies are needed to investigate the long-term association between diet and IBD.
Authors: Chun-Han Lo; Neha Khandpur; Sinara Laurini Rossato; Paul Lochhead; Emily W Lopes; Kristin E Burke; James M Richter; Mingyang Song; Andres Victor Ardisson Korat; Qi Sun; Teresa T Fung; Hamed Khalili; Andrew T Chan; Ashwin N Ananthakrishnan Journal: Clin Gastroenterol Hepatol Date: 2021-08-28 Impact factor: 13.576
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