Qian Li1, Lei Jiang2, Shishou Wu2, Yunjun Wang2, Xiaojie Wang3, Guohua Yu2. 1. Department of Research, Affiliated Yantai Yuhuangding Hospital, Qingdao University 20 Yuhuangding East Road, Yantai 264000, China. 2. Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Qingdao University 20 Yuhuangding East Road, Yantai 264000, China. 3. Department of Gynecology, Affiliated Yantai Yuhuangding Hospital, Qingdao University 20 Yuhuangding East Road, Yantai 264000, China.
Abstract
OBJECTS: To investigate the pathologic characteristic of discordant lymphoma with mantle cell lymphoma and angioimmunoblastic T cell lymphoma. METHODS: The clinicopathologic data of cases of discordant lymphoma were organized and clinicopathologic features were analyzed by literature review. RESULTS: A 49-year-old male was taken to the hospital due to the lymphandenopathy in January 2007 and mantle cell lymphoma was diagnosed in the pathology report. EBV-EBER staining was negative. Active chemotherapy was received and the patient achieved complete response. Seven years later since diagnosis, in 2014 scattered rashes were found. A skin biopsy was taken and the result was not mantle cell lymphoma but angioimmunoblastic T cell lymphoma. EBV-EBER positivity was detected. Clonal T cell receptor gamma locus gene rearrangements were detected while no clonal immunoglobin heavy locus gene rearrangement was detected in the skin sample. CONCLUSIONS: This is the first report on discordant lymphoma consisting of mantle cell lymphoma and angioimmunoblastic T cell lymphoma. There seems to be no relation these two different kinds of lymphoma, and EBV infection might prompt the development of angioimmunoblastic T cell lymphoma after transplantation. Rash is a common clinical manifestation when T cell lymphoma develops after treatment for MCL. IJCEP
OBJECTS: To investigate the pathologic characteristic of discordant lymphoma with mantle cell lymphoma and angioimmunoblastic T cell lymphoma. METHODS: The clinicopathologic data of cases of discordant lymphoma were organized and clinicopathologic features were analyzed by literature review. RESULTS: A 49-year-old male was taken to the hospital due to the lymphandenopathy in January 2007 and mantle cell lymphoma was diagnosed in the pathology report. EBV-EBER staining was negative. Active chemotherapy was received and the patient achieved complete response. Seven years later since diagnosis, in 2014 scattered rashes were found. A skin biopsy was taken and the result was not mantle cell lymphoma but angioimmunoblastic T cell lymphoma. EBV-EBER positivity was detected. Clonal T cell receptor gamma locus gene rearrangements were detected while no clonal immunoglobin heavy locus gene rearrangement was detected in the skin sample. CONCLUSIONS: This is the first report on discordant lymphoma consisting of mantle cell lymphoma and angioimmunoblastic T cell lymphoma. There seems to be no relation these two different kinds of lymphoma, and EBV infection might prompt the development of angioimmunoblastic T cell lymphoma after transplantation. Rash is a common clinical manifestation when T cell lymphoma develops after treatment for MCL. IJCEP
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