Literature DB >> 32055

Measurement of beta-adrenoceptor antagonists in biological fluids using a radioreceptor assay.

S R Nahorski, M I Batta, D B Barnett.   

Abstract

A new assay for plasma levels of beta-adrenoceptor antagonists is described. The assay depends upon the ability of the drug to compete with a labelled beta-adrenoceptor antagonist (-)-[3H]dihydroalprenolol for beta-adrenoceptor binding sites on lung membranes. The assay is simple to perform, very sensitive and does not require prior extraction of plasma. The assay can also detect bioactive metabolites of these agents and is clearly not limited to a single beta-adrenoceptor antagonist.

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Year:  1978        PMID： 32055     DOI： 10.1016/0014-2999(78)90296-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  5 in total

Review 1.  Radioligand binding studies of adrenergic receptors and their clinical relevance.

Authors:  P J Barnes
Journal:  Br Med J (Clin Res Ed)       Date:  1981-04-11

2.  Analysis of the activity and distribution of beta-adrenoceptor antagonists in the rat using an ex vivo receptor binding assay [proceedings].

Authors:  S R Nahorski; K Sriwatanakul
Journal:  Br J Pharmacol       Date:  1979-11       Impact factor: 8.739

3.  Radioreceptor assay for labetalol.

Authors:  J G Kelly; K McGarry; K O'Malley
Journal:  Br J Clin Pharmacol       Date:  1981-08       Impact factor: 4.335

4.  Proceeding of the British Pharmacological Society, Clinical Pharmacology Section, 16-18th December, 1980, University of London. Abstracts.

Authors: 
Journal:  Br J Clin Pharmacol       Date:  1981-04       Impact factor: 4.335

5.  Evaluation of a radioreceptor assay for beta-adrenoceptor antagonists in plasma.

Authors:  D B Barnett; M Batta; B Davies; S R Nahorski
Journal:  Eur J Clin Pharmacol       Date:  1980-05       Impact factor: 2.953
  5 in total

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