Literature DB >> 3205310

[What do we know about the molecular mechanism of visual excitation?].

H Stieve1.   

Abstract

The mechanism of transduction of the light stimulus into an electrical response signal is described for visual cells of vertebrates and invertebrates. Absorption of a photon by a rhodopsin molecule in the photosensory membrane of the visual cell leads to a delayed, relatively large single-photon-evoked response, the elementary excitatory response. The rhodopsin molecule starts an enzyme cascade via a G-protein. This leads to a considerably amplified decrease (vertebrates), or increase (invertebrates) of a large number of intracellular messenger molecules. Binding of these messenger molecules causes the opening of the sodium-preferring ion channels in the plasma membrane. Our present knowledge of the molecular mechanisms involved is described.

Entities:  

Mesh:

Substances:

Year:  1988        PMID: 3205310     DOI: 10.1007/bf00367319

Source DB:  PubMed          Journal:  Naturwissenschaften        ISSN: 0028-1042


  10 in total

Review 1.  Ionic conductances in rod photoreceptors.

Authors:  W G Owen
Journal:  Annu Rev Physiol       Date:  1987       Impact factor: 19.318

2.  Cyclic GMP is involved in the excitation of invertebrate photoreceptors.

Authors:  E C Johnson; P R Robinson; J E Lisman
Journal:  Nature       Date:  1986 Dec 4-10       Impact factor: 49.962

3.  Electrophysiological study of the mechanisms subserving color coding in the fish retina.

Authors:  T Tomita
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1965

Review 4.  Molecular biology of the visual pigments.

Authors:  M L Applebury; P A Hargrave
Journal:  Vision Res       Date:  1986       Impact factor: 1.886

5.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors:  O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal:  Pflugers Arch       Date:  1981-08       Impact factor: 3.657

6.  The structure of bovine rhodopsin.

Authors:  P A Hargrave; J H McDowell; D R Curtis; J K Wang; E Juszczak; S L Fong; J K Rao; P Argos
Journal:  Biophys Struct Mech       Date:  1983

7.  Photoreceptor excitation and adaptation by inositol 1,4,5-trisphosphate.

Authors:  A Fein; R Payne; D W Corson; M J Berridge; R F Irvine
Journal:  Nature       Date:  1984 Sep 13-19       Impact factor: 49.962

8.  Single-channel currents activated by light in Limulus ventral photoreceptors.

Authors:  J Bacigalupo; J E Lisman
Journal:  Nature       Date:  1983 Jul 21-27       Impact factor: 49.962

9.  Identification, purification, and functional reconstitution of the cyclic GMP-dependent channel from rod photoreceptors.

Authors:  N J Cook; W Hanke; U B Kaupp
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

10.  Pressure injection of calcium both excites and adapts Limulus ventral photoreceptors.

Authors:  R Payne; D W Corson; A Fein
Journal:  J Gen Physiol       Date:  1986-07       Impact factor: 4.086

  10 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.