Jan Scott1,2, Nicholas G Martin3, Richard Parker3, Baptiste Couvy-Duchesne3,4,5, Sarah E Medland3, Ian Hickie1. 1. Brain and Mind Centre, The University of Sydney, Sydney, Australia. 2. Institute of Neuroscience, Newcastle University, Newcastle, United Kingdom. 3. QIMR Berghofer Institute of Medical Research, Brisbane, Australia. 4. Institute of Molecular Bioscience, The University of Queensland, Brisbane, Australia. 5. Brain and Spine Institute (ICM), Paris, France.
Abstract
AIM: Subthreshold syndromes (STS) frequently precede the onset of full-threshold syndromes (FTS) of the corresponding mental disorder (homotypic continuity). This study examines whether subthreshold conditions are comorbid and whether there is heterotypic continuity also between STS and FTS. METHODS: Data were extracted from the Brisbane "19Up" cohort study of twins and siblings (N = 1838; 56% female) on individuals who (i) completed self-report ratings of depression-like (DLE), hypomanic-like (HMLE) and psychotic-like experiences (PLE) and (ii) were assessed for mood and psychotic FTS using the Composite International Diagnostic Interview (CIDI). Associations between STS and FTS were estimated using adjusted prevalence ratios (APR) and 95% confidence intervals (CI). RESULTS: STS are prevalent, with 22% reporting DLE, 14% HMLE and 5% PLE; 7% reported >1 STS, with PLE most likely to demonstrate comorbidity. Individuals with DLE were likely to meet CIDI criteria for depression (APR: 3.71, 95% CI: 2.83, 4.89), hypo/mania (APR: 3.62, 95% CI: 2.21, 5.94) and psychotic disorders (APR: 1.74, 95% CI 1.08, 2.83). Individuals with HMLE were likely to meet CIDI criteria for depression (APR: 2.29, 95% CI: 1.58, 3.31) and hypo/mania (APR: 2.51, 95% CI: 1.29, 4.91); those with PLE were likely to meet criteria for hypo/mania (APR: 5.8, 95% CI: 1.90, 17.70) and psychotic disorders (APR: 17.27, 95% CI: 7.54, 39.65). CONCLUSIONS: The findings suggest that STS are common among young adults and show heterotypic as well as homotypic continuity with FTS and support the need for more trans-diagnostic research on the evolution of major mental disorders.
AIM: Subthreshold syndromes (STS) frequently precede the onset of full-threshold syndromes (FTS) of the corresponding mental disorder (homotypic continuity). This study examines whether subthreshold conditions are comorbid and whether there is heterotypic continuity also between STS and FTS. METHODS: Data were extracted from the Brisbane "19Up" cohort study of twins and siblings (N = 1838; 56% female) on individuals who (i) completed self-report ratings of depression-like (DLE), hypomanic-like (HMLE) and psychotic-like experiences (PLE) and (ii) were assessed for mood and psychotic FTS using the Composite International Diagnostic Interview (CIDI). Associations between STS and FTS were estimated using adjusted prevalence ratios (APR) and 95% confidence intervals (CI). RESULTS: STS are prevalent, with 22% reporting DLE, 14% HMLE and 5% PLE; 7% reported >1 STS, with PLE most likely to demonstrate comorbidity. Individuals with DLE were likely to meet CIDI criteria for depression (APR: 3.71, 95% CI: 2.83, 4.89), hypo/mania (APR: 3.62, 95% CI: 2.21, 5.94) and psychotic disorders (APR: 1.74, 95% CI 1.08, 2.83). Individuals with HMLE were likely to meet CIDI criteria for depression (APR: 2.29, 95% CI: 1.58, 3.31) and hypo/mania (APR: 2.51, 95% CI: 1.29, 4.91); those with PLE were likely to meet criteria for hypo/mania (APR: 5.8, 95% CI: 1.90, 17.70) and psychotic disorders (APR: 17.27, 95% CI: 7.54, 39.65). CONCLUSIONS: The findings suggest that STS are common among young adults and show heterotypic as well as homotypic continuity with FTS and support the need for more trans-diagnostic research on the evolution of major mental disorders.
Authors: Jacob J Crouse; Nicholas Ho; Jan Scott; Richard Parker; Shin Ho Park; Baptiste Couvy-Duchesne; Brittany L Mitchell; Enda M Byrne; Daniel F Hermens; Sarah E Medland; Nicholas G Martin; Nathan A Gillespie; Ian B Hickie Journal: Eur Psychiatry Date: 2022-06-13 Impact factor: 7.156
Authors: Jan Scott; Jacob J Crouse; Nicholas Ho; Joanne Carpenter; Nicholas Martin; Sarah Medland; Richard Parker; Enda Byrne; Baptiste Couvy-Duchesne; Brittany Mitchell; Kathleen Merikangas; Nathan A Gillespie; Ian Hickie Journal: Bipolar Disord Date: 2021-03-08 Impact factor: 5.345
Authors: Jacob J Crouse; Nicholas Ho; Jan Scott; Nicholas G Martin; Baptiste Couvy-Duchesne; Daniel F Hermens; Richard Parker; Nathan A Gillespie; Sarah E Medland; Ian B Hickie Journal: Transl Psychiatry Date: 2021-05-13 Impact factor: 6.222