Literature DB >> 32052477

The relevance of soluble CD137 in the regulation of immune responses and for immunotherapeutic intervention.

Khang Luu1,2, Zhe Shao1, Herbert Schwarz1,2.   

Abstract

CD137 is a potent costimulatory receptor. Several agonistic anti-CD137 antibodies are currently in clinical trials for tumor immunotherapy. Soluble forms of CD137 (sCD137) are generated by differential splicing and antagonize the activities of membrane-bound CD137 (mCD137) and of therapeutic CD137 agonists. sCD137 is found in sera of patients suffering from autoimmune diseases where it is a natural regulator of immune responses, and which has therapeutic potential for immune-mediated diseases. This review summarizes the current knowledge on sCD137, highlights its potential role in immunotherapy against cancer and in autoimmune diseases, and presents important issues to be addressed by future research. ©2020 Society for Leukocyte Biology.

Entities:  

Keywords:  CD137; autoimmune; cytokine receptor; soluble

Year:  2020        PMID： 32052477     DOI： 10.1002/JLB.2MR1119-224R

Source DB:  PubMed          Journal:  J Leukoc Biol        ISSN： 0741-5400            Impact factor:   4.962


  8 in total

1.  Recombinant CD137-Fc, its synthesis, and applications for improving the immune system functions, such as tumor immunotherapy and to reduce the inflammation due to the novel coronavirus.

Authors:  Maryam Ajami; Mahboobeh Nazari; Habibollah Mahmoodzadeh; Seyed Mohammad Moazzeni
Journal:  J Cell Biochem       Date:  2021-05-16       Impact factor: 4.429

2.  Elevated soluble 4-1BB is associated with serum markers of hepatitis B virus in patients with chronic hepatitis B.

Authors:  Meng-Ru Zhan; Xiu-Zhu Gao; Chang Wang; Fei Peng; Xiao-Mei Wang; Hong-Qin Xu; Jun-Qi Niu
Journal:  World J Clin Cases       Date:  2021-03-06       Impact factor: 1.337

3.  Systemic viral spreading and defective host responses are associated with fatal Lassa fever in macaques.

Authors:  Nicolas Baillet; Stéphanie Reynard; Emeline Perthame; Jimmy Hortion; Alexandra Journeaux; Mathieu Mateo; Xavier Carnec; Justine Schaeffer; Caroline Picard; Laura Barrot; Stéphane Barron; Audrey Vallve; Aurélie Duthey; Frédéric Jacquot; Cathy Boehringer; Grégory Jouvion; Natalia Pietrosemoli; Rachel Legendre; Marie-Agnès Dillies; Richard Allan; Catherine Legras-Lachuer; Caroline Carbonnelle; Hervé Raoul; Sylvain Baize
Journal:  Commun Biol       Date:  2021-01-04

4.  Soluble CD137 as a dynamic biomarker to monitor agonist CD137 immunotherapies.

Authors:  Javier Glez-Vaz; Arantza Azpilikueta; Irene Olivera; Assunta Cirella; Alvaro Teijeira; Maria C Ochoa; Maite Alvarez; Iñaki Eguren-Santamaria; Carlos Luri-Rey; Maria E Rodriguez-Ruiz; Xinxin Nie; Lieping Chen; Sonia Guedan; Miguel F Sanamed; Jose Luis Perez Gracia; Ignacio Melero
Journal:  J Immunother Cancer       Date:  2022-03       Impact factor: 13.751

5.  Circulating immune profile can predict survival of metastatic uveal melanoma patients: results of an exploratory study.

Authors:  Ernesto Rossi; Ilaria Grazia Zizzari; Alessandra Di Filippo; Anna Acampora; Monica Maria Pagliara; Maria Grazia Sammarco; Maurizio Simmaco; Luana Lionetto; Andrea Botticelli; Emilio Bria; Paolo Marchetti; Maria Antonietta Blasi; Giampaolo Tortora; Giovanni Schinzari; Marianna Nuti
Journal:  Hum Vaccin Immunother       Date:  2022-03-08       Impact factor: 4.526

Review 6.  The long and winding road: From mouse linkage studies to a novel human therapeutic pathway in type 1 diabetes.

Authors:  Manuel Rojas; Luke S Heuer; Weici Zhang; Yi-Guang Chen; William M Ridgway
Journal:  Front Immunol       Date:  2022-07-22       Impact factor: 8.786

7.  Role of ADAM10 and ADAM17 in Regulating CD137 Function.

Authors:  Jana Seidel; Sinje Leitzke; Björn Ahrens; Maria Sperrhacke; Sucharit Bhakdi; Karina Reiss
Journal:  Int J Mol Sci       Date:  2021-03-08       Impact factor: 5.923

8.  Soluble Immune Checkpoints, Gut Metabolites and Performance Status as Parameters of Response to Nivolumab Treatment in NSCLC Patients.

Authors:  Ilaria Grazia Zizzari; Alessandra Di Filippo; Fabio Scirocchi; Francesca Romana Di Pietro; Hassan Rahimi; Alessio Ugolini; Simone Scagnoli; Pamela Vernocchi; Federica Del Chierico; Lorenza Putignani; Aurelia Rughetti; Paolo Marchetti; Marianna Nuti; Andrea Botticelli; Chiara Napoletano
Journal:  J Pers Med       Date:  2020-11-04
  8 in total

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