Literature DB >> 32051983

Interference of pH buffer with Pb2+-peripheral domain interactions: obstacle or opportunity?

Sachin Katti1, Tatyana I Igumenova.   

Abstract

Pb2+ is a xenobiotic metal ion that competes for Ca2+-binding sites in proteins. Using the peripheral Ca2+-sensing domains of Syt1, we show that the chelating pH buffer Bis-Tris enables identification and functional characterization of high-affinity Pb2+ sites that are likely to be targeted by bioavailable Pb2+.

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Year:  2020        PMID： 32051983      PMCID： PMC7357838          DOI： 10.1039/d0mt00002g

Source DB:  PubMed          Journal:  Metallomics        ISSN： 1756-5901            Impact factor:   4.526


  36 in total

1.  Study of the neurochemical alterations produced in discrete brain areas by perinatal low-level lead exposure.

Authors:  M T Antonio; M L Leret
Journal:  Life Sci       Date:  2000-06-30       Impact factor: 5.037

Review 2.  Very low lead exposures and children's neurodevelopment.

Authors:  David C Bellinger
Journal:  Curr Opin Pediatr       Date:  2008-04       Impact factor: 2.856

3.  Phosphatidylinositol 4,5-bisphosphate increases Ca2+ affinity of synaptotagmin-1 by 40-fold.

Authors:  Geert van den Bogaart; Karsten Meyenberg; Ulf Diederichsen; Reinhard Jahn
Journal:  J Biol Chem       Date:  2012-03-23       Impact factor: 5.157

4.  Synaptotagmin I functions as a calcium regulator of release probability.

Authors:  R Fernández-Chacón; A Königstorfer; S H Gerber; J García; M F Matos; C F Stevens; N Brose; J Rizo; C Rosenmund; T C Südhof
Journal:  Nature       Date:  2001-03-01       Impact factor: 49.962

Review 5.  Lead neurotoxicity in children: basic mechanisms and clinical correlates.

Authors:  Theodore I Lidsky; Jay S Schneider
Journal:  Brain       Date:  2003-01       Impact factor: 13.501

6.  High affinity interactions of Pb2+ with synaptotagmin I.

Authors:  Sachin Katti; Bin Her; Atul K Srivastava; Alexander B Taylor; Steve W Lockless; Tatyana I Igumenova
Journal:  Metallomics       Date:  2018-09-19       Impact factor: 4.526

7.  Effect of in vitro inorganic lead on dopamine release from superfused rat striatal synaptosomes.

Authors:  D J Minnema; R D Greenland; I A Michaelson
Journal:  Toxicol Appl Pharmacol       Date:  1986-06-30       Impact factor: 4.219

8.  Presynaptic glutamatergic function in dentate gyrus in vivo is diminished by chronic exposure to inorganic lead.

Authors:  S M Lasley; M E Gilbert
Journal:  Brain Res       Date:  1996-10-14       Impact factor: 3.252

9.  Close membrane-membrane proximity induced by Ca(2+)-dependent multivalent binding of synaptotagmin-1 to phospholipids.

Authors:  Demet Araç; Xiaocheng Chen; Htet A Khant; Josep Ubach; Steven J Ludtke; Masahide Kikkawa; Arthur E Johnson; Wah Chiu; Thomas C Südhof; Josep Rizo
Journal:  Nat Struct Mol Biol       Date:  2006-02-19       Impact factor: 15.369

10.  Solution and membrane-bound conformations of the tandem C2A and C2B domains of synaptotagmin 1: Evidence for bilayer bridging.

Authors:  Dawn Z Herrick; Weiwei Kuo; Hao Huang; Charles D Schwieters; Jeffrey F Ellena; David S Cafiso
Journal:  J Mol Biol       Date:  2009-06-06       Impact factor: 5.469
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