Catherine Gire1,2, Barthélémy Tosello3,4, Stéphane Marret5, Gilles Cambonie6, Isabelle Souksi-Medioni7, Jean-Baptiste Müller8, Patricia Garcia9, Julie Berbis10, Pascal Auquier10, Véronique Brévaut-Malaty3, Noémie Resseguier10. 1. Department of Neonatology, North Hospital, APHM University Hospital, Chemin des Bourrely, 13015, Marseille, France. catherine.gire@ap-hm.fr. 2. EA3279, Self-Perceived Health Assessment Research Unit, Faculty of Medicine, Marseille, 13385, France. catherine.gire@ap-hm.fr. 3. Department of Neonatology, North Hospital, APHM University Hospital, Chemin des Bourrely, 13015, Marseille, France. 4. Aix-Marseille Univ, CNRS, EFS, ADES, Marseille, France. 5. Department of Neonatal Medicine, Rouen University Hospital and INSERM U1245, Neovasc team, Perinatal neurological handicap and Neuroprotection IRIB, Faculty of Medicine, Rouen, France. 6. Department of Neonatal Medicine, Montpellier University Hospital, Montpellier, France. 7. Department of Neonatal Medicine, Nimes University Hospital, Nimes, France. 8. Department of Neonatal Medicine, Nantes University Hospital, Nantes, France. 9. Department of Neonatology, Conception Hospital, APHM University Hospital, Marseille, France. 10. EA3279, Self-Perceived Health Assessment Research Unit, Faculty of Medicine, Marseille, 13385, France.
Abstract
BACKGROUND: We examined how specific cognitive behavioral impairments impacted quality of life (QoL) within a large multicenter cohort of 7-10 year olds surviving extremely preterm (EPT) without major neurodevelopmental disability. METHODS: Between 7 and 10 years of age, two generic, self-proxy, and parental evaluations were obtained. QoL measurement questionnaires (Kidscreen-10/VSPA (Vécu et Santé Perçue de l'Enfant et de l'Adolescent)) were used and compared to a reference population. The general and specific cognitive functions, such as executive functions, behavior and anxiety, and clinical neurologic examination, were also assessed. RESULTS: We analyzed 211 school-aged EPT children. The mean gestational age was 26.2 (±0.8) weeks, birth weight was 879 g (±181) and the mean age was 8.4 years (±0.87). Children with a Full-Scale Index Quotient ≥89, who were considered as normal, had a lower QoL. Specific cognitive impairments: comprehensive language delay, visuo-spatial integration defect, and dysexecutive disorders) were the QoL correlates in the domains of school performance and body image. CONCLUSIONS: School and health care professionals need to increase their focus on EPT children's lower so as to recognize the preterm behavioral/cognitive phenotype and their potential need for supportive measures. Research on preventive interventions is warranted to investigate if these long-term effects of an EPT birth can be attenuated in neonatal period and after.
BACKGROUND: We examined how specific cognitive behavioral impairments impacted quality of life (QoL) within a large multicenter cohort of 7-10 year olds surviving extremely preterm (EPT) without major neurodevelopmental disability. METHODS: Between 7 and 10 years of age, two generic, self-proxy, and parental evaluations were obtained. QoL measurement questionnaires (Kidscreen-10/VSPA (Vécu et Santé Perçue de l'Enfant et de l'Adolescent)) were used and compared to a reference population. The general and specific cognitive functions, such as executive functions, behavior and anxiety, and clinical neurologic examination, were also assessed. RESULTS: We analyzed 211 school-aged EPT children. The mean gestational age was 26.2 (±0.8) weeks, birth weight was 879 g (±181) and the mean age was 8.4 years (±0.87). Children with a Full-Scale Index Quotient ≥89, who were considered as normal, had a lower QoL. Specific cognitive impairments: comprehensive language delay, visuo-spatial integration defect, and dysexecutive disorders) were the QoL correlates in the domains of school performance and body image. CONCLUSIONS: School and health care professionals need to increase their focus on EPT children's lower so as to recognize the preterm behavioral/cognitive phenotype and their potential need for supportive measures. Research on preventive interventions is warranted to investigate if these long-term effects of an EPT birth can be attenuated in neonatal period and after.
Authors: Giovanni Mento; Lisa Toffoli; Letizia Della Longa; Teresa Farroni; Fiorella Del Popolo Cristaldi; Gian Marco Duma Journal: Brain Sci Date: 2022-08-13