Literature DB >> 32049042

Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects.

Sarah-Maria Fendt1, Sophia Y Lunt2.   

Abstract

The role of ROS in cancer is complex, with studies demonstrating both pro- and anti-tumor effects. In a pancreatic ductal adenocarcinoma model, ROS limitation through TIGAR has been shown to initially support cancer development but to later become a metabolic liability in metastasizing cells that is counteracted by decreased TIGAR expression.
Copyright © 2020 Elsevier Inc. All rights reserved.

Entities:  

Year:  2020        PMID： 32049042     DOI： 10.1016/j.ccell.2020.01.009

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  8 in total

Review 1.  Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take.

Authors:  Patricia Altea-Manzano; Alejandro M Cuadros; Lindsay A Broadfield; Sarah-Maria Fendt
Journal:  EMBO Rep       Date:  2020-09-23       Impact factor: 8.807

2.  Neferine induces apoptosis by modulating the ROS‑mediated JNK pathway in esophageal squamous cell carcinoma.

Authors:  Kang An; Yuehan Zhang; Yingjiao Liu; Shengxi Yan; Zhaowei Hou; Meng Cao; Guangkuo Liu; Congcong Dong; Juncha Gao; Gaifang Liu
Journal:  Oncol Rep       Date:  2020-07-07       Impact factor: 3.906

Review 3.  Oncology Therapeutics Targeting the Metabolism of Amino Acids.

Authors:  Nefertiti Muhammad; Hyun Min Lee; Jiyeon Kim
Journal:  Cells       Date:  2020-08-15       Impact factor: 6.600

4.  Chlorin e6-Induced Photodynamic Effect Polarizes the Macrophage Into an M1 Phenotype Through Oxidative DNA Damage and Activation of STING.

Authors:  Ting-Ting Yu; Ning Han; Liu-Gen Li; Xing-Chun Peng; Qi-Rui Li; Hua-Zhen Xu; Xi-Yong Wang; Zi-Yi Yang; Xiao Chen; Mei-Fang Wang; Tong-Fei Li
Journal:  Front Pharmacol       Date:  2022-03-03       Impact factor: 5.810

Review 5.  Metabolic Adaptation-Mediated Cancer Survival and Progression in Oxidative Stress.

Authors:  Yongquan Tang; Zhe Zhang; Yan Chen; Siyuan Qin; Li Zhou; Wei Gao; Zhisen Shen
Journal:  Antioxidants (Basel)       Date:  2022-07-05

6.  Acetone Extract of Cornus officinalis Leaves Exerts Anti-Melanoma Effects via Inhibiting STAT3 Signaling.

Authors:  Ruiqi Xu; Mengnan Zeng; Yuanyuan Wu; Shengchao Wang; Beibei Zhang; Jingke Zhang; Yuxuan Kan; Benke Li; Bing Cao; Xiaoke Zheng; Weisheng Feng
Journal:  Onco Targets Ther       Date:  2021-05-28       Impact factor: 4.147

7.  Markers of Prognosis for Early Stage Cervical Cancer Patients (Stage IB1, IB2) Undergoing Surgical Treatment.

Authors:  Chen Xu; Tie Ma; Hongzan Sun; Xiaohan Li; Song Gao
Journal:  Front Oncol       Date:  2021-06-02       Impact factor: 6.244

8.  Cepharanthine sensitizes human triple negative breast cancer cells to chemotherapeutic agent epirubicin via inducing cofilin oxidation-mediated mitochondrial fission and apoptosis.

Authors:  Li-Wen Shen; Xiu-Xing Jiang; Zhi-Qiang Li; Jie Li; Mei Wang; Guan-Fei Jia; Xin Ding; Ling Lei; Qi-Hai Gong; Ning Gao
Journal:  Acta Pharmacol Sin       Date:  2021-07-22       Impact factor: 6.150
  8 in total

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