Literature DB >> 32048639

Fluorescence detection of metabolic activity of the fatty acid beta oxidation pathway in living cells.

Shohei Uchinomiya1, Naoya Matsunaga1, Koichiro Kamoda1, Ryosuke Kawagoe1, Akito Tsuruta1, Shigehiro Ohdo1, Akio Ojida1.   

Abstract

Detection of metabolic activity in living cells facilitates the understanding of the cell mechanism. Here, we report a fluorescent probe that can detect fatty acid beta oxidation (FAO) in living cells. This probe is metabolically degraded by the sequential enzyme reactions of FAO and can visualize the FAO activity with turn-on fluorescence.

Entities:  

Year:  2020        PMID: 32048639     DOI: 10.1039/c9cc09993j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  3 in total

1.  Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity.

Authors:  Hong Yao; Minghui Liu; Leibo Wang; Yumeng Zu; Chou Wu; Chenyu Li; Ruoxi Zhang; Haigen Lu; Feifei Li; Shuang Xi; Shuangquan Chen; Xuanyu Gu; Tianya Liu; Jie Cai; Shirong Wang; Maojun Yang; Guo-Gang Xing; Wei Xiong; Lan Hua; Yefeng Tang; Gelin Wang
Journal:  Cell Res       Date:  2022-04-22       Impact factor: 46.297

2.  A negative-solvatochromic fluorescent probe for visualizing intracellular distributions of fatty acid metabolites.

Authors:  Keiji Kajiwara; Hiroshi Osaki; Steffen Greßies; Keiko Kuwata; Ju Hyun Kim; Tobias Gensch; Yoshikatsu Sato; Frank Glorius; Shigehiro Yamaguchi; Masayasu Taki
Journal:  Nat Commun       Date:  2022-05-09       Impact factor: 17.694

3.  Systemic lipolysis promotes physiological fitness in Drosophila melanogaster.

Authors:  Linshan Shang; Elizabeth Aughey; Huiseon Kim; Timothy D Heden; Lu Wang; Charles P Najt; Nicholas Esch; Sophia Brunko; Juan E Abrahante; Marissa Macchietto; Mara T Mashek; Todd Fairbanks; Daniel E L Promislow; Thomas P Neufeld; Douglas G Mashek
Journal:  Aging (Albany NY)       Date:  2022-08-30       Impact factor: 5.955

  3 in total

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