B Vischioni1, B Dhanireddy2, C Severo3, M Bonora4, S Ronchi4, V Vitolo4, M R Fiore4, E D'Ippolito4, R Petrucci4, A Barcellini4, E Ciurlia5, A Iannalfi4, A Hasegawa6, S Molinelli6, A Mirandola6, F Valvo4, R Orecchia7. 1. Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy. Electronic address: barbara.vischioni@cnao.it. 2. Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy; Radiation Medicine, Albert B. Chandler Hospital, University of Kentucky, USA. 3. Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy; Section of Radiological Sciences, University of Messina, Messina, Italy. 4. Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy. 5. Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy; Radiation Oncology Department, Vito Fazzi Hospital, Lecce, Italy. 6. Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy; Radiation Oncology Department, Osaka Heavy Ion Therapy Center, Osaka, Japan. 7. Radiation Oncology Clinical Department, National Center for Oncological Hadrontherapy (CNAO), Pavia, Italy; Department of Radiotherapy, European Institute of Oncology, Milan, Italy.
Abstract
AIMS: To report oncologic and functional outcomes in terms of tumor control and toxicity of carbon ion radiotherapy (CIRT) in reirradiation setting for recurrent salivary gland tumors at CNAO. METHODS: From November 2013 to September 2016, 51 consecutive patients with inoperable recurrent salivary gland tumors were retreated with CIRT in the frame of the phase II protocol CNAO S14/2012C for recurrent head and neck tumors. RESULTS: Majority of pts (74.5%) had adenoid cystic carcinoma, mainly rcT4a (51%) and rcT4b (37%). Median dose of prior photon based radiotherapy was 60 Gy. Median dose of CIRT was 60 Gy [RBE] at a mean of 3 Gy [RBE] per fraction. During reirradiation, 19 patients (37.3%) experienced grade G1 toxicity, 19 pts (37.3%) had G2 and 2 pts (3.9%) had G3. Median follow up time was 19 months. Twenty one (41.2%) patients had stable disease and 30 (58.8%) tumor progression at the time of last follow up. Furthermore, 9 (18%) patients had G1 late toxicity, 19 (37%) had G2 and 9 (17. 5%) had G3. Using the Kaplan Meier method, progression free survival (actuarial) at one and two years were 71.7% and 52.2% respectively. Estimated overall survival (actuarial) at one and two years were 90.2% and 64%, respectively. CONCLUSIONS: CIRT is a good option for retreatment of inoperable recurrent salivary gland tumors with acceptable rates of acute and late toxicity. Longer follow up time is needed to assess the effectiveness of CIRT in reirradiation setting of salivary gland tumors.
AIMS: To report oncologic and functional outcomes in terms of tumor control and toxicity of carbon ion radiotherapy (CIRT) in reirradiation setting for recurrent salivary gland tumors at CNAO. METHODS: From November 2013 to September 2016, 51 consecutive patients with inoperable recurrent salivary gland tumors were retreated with CIRT in the frame of the phase II protocol CNAO S14/2012C for recurrent head and neck tumors. RESULTS: Majority of pts (74.5%) had adenoid cystic carcinoma, mainly rcT4a (51%) and rcT4b (37%). Median dose of prior photon based radiotherapy was 60 Gy. Median dose of CIRT was 60 Gy [RBE] at a mean of 3 Gy [RBE] per fraction. During reirradiation, 19 patients (37.3%) experienced grade G1 toxicity, 19 pts (37.3%) had G2 and 2 pts (3.9%) had G3. Median follow up time was 19 months. Twenty one (41.2%) patients had stable disease and 30 (58.8%) tumor progression at the time of last follow up. Furthermore, 9 (18%) patients had G1 late toxicity, 19 (37%) had G2 and 9 (17. 5%) had G3. Using the Kaplan Meier method, progression free survival (actuarial) at one and two years were 71.7% and 52.2% respectively. Estimated overall survival (actuarial) at one and two years were 90.2% and 64%, respectively. CONCLUSIONS: CIRT is a good option for retreatment of inoperable recurrent salivary gland tumors with acceptable rates of acute and late toxicity. Longer follow up time is needed to assess the effectiveness of CIRT in reirradiation setting of salivary gland tumors.
Authors: Edoardo Mastella; Silvia Molinelli; Giuseppe Magro; Stefania Russo; Maria Bonora; Sara Ronchi; Rossana Ingargiola; Alexandra D Jensen; Mario Ciocca; Barbara Vischioni; Ester Orlandi Journal: Front Oncol Date: 2021-12-13 Impact factor: 6.244
Authors: Barbara Vischioni; Stefania Russo; Martino Meuli; Maria Bonora; Sara Ronchi; Rossana Ingargiola; Anna Maria Camarda; Sara Imparato; Lorenzo Preda; Mario Ciocca; Silvia Molinelli; Ester Orlandi Journal: Front Oncol Date: 2022-03-02 Impact factor: 6.244
Authors: Mauricio E Gamez; Samir H Patel; Lisa A McGee; Terence T Sio; Mark McDonald; Jack Phan; Daniel J Ma; Robert L Foote; Jean-Claude M Rwigema Journal: Int J Part Ther Date: 2021-06-25
Authors: Sara Ronchi; Barbara Vischioni; Maria Bonora; Amelia Barcellini; Laura D Locati; Paolo Castelnuovo; Piero Nicolai; Cesare Piazza; Mohssen Ansarin; Marco Benazzo; Ester Orlandi Journal: Oral Oncol Date: 2020-05-14 Impact factor: 5.337