| Literature DB >> 32044515 |
Yu-Fei Xi1, Li-Li Lou2, Feng-Ying Han1, Si-Fan Liu1, Guo-Dong Yao1, Bin Lin3, Xiao-Xiao Huang1, Xiao-Bo Wang4, Shao-Jiang Song5.
Abstract
In the current study, four pairs of new enantiomeric alkaloids (1a/1b-4a/4b) were obtained from the leaves of Isatis indigotica Fortune Ex Land. Their structures were elucidated through spectroscopic methods and quantum mechanical calculations. Biologically, all isolates were evaluated for their neuroprotective effects against H2O2-induced SH-SY5Y cell injury. As a result, 1a and 1b exhibited enantioselective neuroprotective effects, further Annexin V-FITC/PI analysis showed that apoptosis ratios of 1a and 1b were reduced to 20.93% and 17.87%, respectively.Entities:
Keywords: Apoptosis; Enantiomeric alkaloids; Isatis indigotica; Neuroprotective effects
Mesh：
Substances：
Year: 2020 PMID： 32044515 DOI： 10.1016/j.bioorg.2020.103650
Source DB: PubMed Journal: Bioorg Chem ISSN： 0045-2068 Impact factor: 5.275