Wieland Elger1,2, Christina Illge1, Wieland Kiess2,3, Antje Körner2,3, Jürgen Kratzsch4, Annett Schrock1, Christian Hirsch1,2. 1. Department of Pediatric Dentistry, University of Leipzig, Leipzig, Germany. 2. LIFE Leipzig Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. 3. Department of Women and Child Health, Hospital for Children and Adolescents and Center for Pediatric Research (CPL), University of Leipzig, Leipzig, Germany. 4. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.
Abstract
BACKGROUND: The aetiology of deciduous molar hypomineralisation (DMH) is still largely unknown. AIM: The aim of the study was to elucidate the occurrence of DMH as a function of the parameters of bone metabolism, as it is suspected that abnormalities in these parameters may affect the mineralisation of teeth. DESIGN: In a prospective cohort study, 958 children aged 1-6 years were examined. The inclusion criteria were: a blood sample to determine the parameters of bone metabolism; and documentation of enamel mineralisation using the European Academy of Paediatric Dentistry (EAPD) criteria. Multivariable methods were applied to analyse the incidence of DMH relative to the concentrations of serum calcium, phosphate, vitamin D, vitamin B12 and alkaline phosphatase, taking into account the effects of age, gender and height. RESULTS: The proportion of children diagnosed with DMH was 4.0% (38 of 958). A significant difference between DMH-affected and non-DMH-affected children was found only in the serum concentration of calcium (2.47 ± 0.08 mmol/l vs. 2.52 ± 0.10 mmol/l, respectively, P = 0.004). The risk of DMH significantly increased, by 1.63-fold (95% CI: 1.03-2.57), if the calcium level dropped by 0.1 mmol/l, regardless of age, gender or adjusted height. During the follow-up examination of 17 DMH-affected subjects, the calcium level remained consistently low 1 year later (t-test, P > 0.05). CONCLUSION: Children with DMH showed consistently subclinically lower serum calcium levels. No associations were found for other parameters.
BACKGROUND: The aetiology of deciduous molar hypomineralisation (DMH) is still largely unknown. AIM: The aim of the study was to elucidate the occurrence of DMH as a function of the parameters of bone metabolism, as it is suspected that abnormalities in these parameters may affect the mineralisation of teeth. DESIGN: In a prospective cohort study, 958 children aged 1-6 years were examined. The inclusion criteria were: a blood sample to determine the parameters of bone metabolism; and documentation of enamel mineralisation using the European Academy of Paediatric Dentistry (EAPD) criteria. Multivariable methods were applied to analyse the incidence of DMH relative to the concentrations of serum calcium, phosphate, vitamin D, vitamin B12 and alkaline phosphatase, taking into account the effects of age, gender and height. RESULTS: The proportion of children diagnosed with DMH was 4.0% (38 of 958). A significant difference between DMH-affected and non-DMH-affected children was found only in the serum concentration of calcium (2.47 ± 0.08 mmol/l vs. 2.52 ± 0.10 mmol/l, respectively, P = 0.004). The risk of DMH significantly increased, by 1.63-fold (95% CI: 1.03-2.57), if the calcium level dropped by 0.1 mmol/l, regardless of age, gender or adjusted height. During the follow-up examination of 17 DMH-affected subjects, the calcium level remained consistently low 1 year later (t-test, P > 0.05). CONCLUSION: Children with DMH showed consistently subclinically lower serum calcium levels. No associations were found for other parameters.
Authors: Marlies E C Elfrink; Annemarie A Schuller; Jaap S J Veerkamp; Jan H G Poorterman; Henriette A Moll; Bob J M ten Cate Journal: Int J Paediatr Dent Date: 2010-03 Impact factor: 3.455
Authors: Markus Loeffler; Christoph Engel; Peter Ahnert; Dorothee Alfermann; Katrin Arelin; Ronny Baber; Frank Beutner; Hans Binder; Elmar Brähler; Ralph Burkhardt; Uta Ceglarek; Cornelia Enzenbach; Michael Fuchs; Heide Glaesmer; Friederike Girlich; Andreas Hagendorff; Madlen Häntzsch; Ulrich Hegerl; Sylvia Henger; Tilman Hensch; Andreas Hinz; Volker Holzendorf; Daniela Husser; Anette Kersting; Alexander Kiel; Toralf Kirsten; Jürgen Kratzsch; Knut Krohn; Tobias Luck; Susanne Melzer; Jeffrey Netto; Matthias Nüchter; Matthias Raschpichler; Franziska G Rauscher; Steffi G Riedel-Heller; Christian Sander; Markus Scholz; Peter Schönknecht; Matthias L Schroeter; Jan-Christoph Simon; Ronald Speer; Julia Stäker; Robert Stein; Yve Stöbel-Richter; Michael Stumvoll; Attila Tarnok; Andrej Teren; Daniel Teupser; Francisca S Then; Anke Tönjes; Regina Treudler; Arno Villringer; Alexander Weissgerber; Peter Wiedemann; Silke Zachariae; Kerstin Wirkner; Joachim Thiery Journal: BMC Public Health Date: 2015-07-22 Impact factor: 3.295
Authors: Marlies E C Elfrink; Henriette A Moll; Jessica C Kiefte-de Jong; Vincent W V Jaddoe; Albert Hofman; Jacob M ten Cate; Jaap S J Veerkamp Journal: PLoS One Date: 2014-07-02 Impact factor: 3.240