| Literature DB >> 32043426 |
Zhiguang Qiao1,2, Jiaxin Tang1,3, Bing Yue4, Jinwu Wang1, Jun Zhang1, Liang Xuan1, Chengxiang Dai5, Suke Li5, Meng Li5, Cuili Xu5, Kerong Dai4, You Wang1,2.
Abstract
Aim: This study aimed to preliminarily evaluate the safety and efficacy of human adipose-derived mesenchymal progenitor cells (haMPCs) in combination with microfracture and hyaluronic acid (HA) for treating cartilage defects. Materials & methods: A total of 30 patients with medial femoro-tibial condylar cartilage defects were randomized into three groups: arthroscopic microfracture group and normal saline injection, arthroscopic microfracture and intra-articular injection of HA, or arthroscopic microfracture in combination with intra-articular injection of HA and haMPCs. Results & conclusions: The data demonstrated that intra-articular injection of haMPCs plus microfracture and HA is a safe procedure to improve joint function in patients with knee cartilage defects. These findings provide an impetus for future research on this treatment. ClinicalTrials.gov Identifier: NCT02855073.Entities:
Keywords: Artz; Re-Join®; cartilage defect; cartilage regeneration; human adipose-derived mesenchymal progenitor cells; microfracture
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Year: 2020 PMID： 32043426 DOI： 10.2217/rme-2019-0068
Source DB: PubMed Journal: Regen Med ISSN： 1746-0751 Impact factor: 3.806