Literature DB >> 32043422

Biosynthetic gene cluster identification and biological activity of lucilactaene from Fusarium sp. RK97-94.

Sho Kato1,2, Takayuki Motoyama1, Yushi Futamura1, Masakazu Uramoto1, Toshihiko Nogawa1, Toshiaki Hayashi1, Hiroshi Hirota1, Akira Tanaka1,3, Naoko Takahashi-Ando3,4, Takashi Kamakura5, Hiroyuki Osada1,2.   

Abstract

We identified the biosynthetic gene cluster for lucilactaene, a cell cycle inhibitor from a filamentous fungus Fusarium sp. RK 97-94. The luc1 knockout strain accumulated demethylated analogs, indicating the involvement of Luc1 methyltransferase in lucilactaene biosynthesis. Lucilactaene showed potent antimalarial activity. Our data suggested that methylation and ether ring formation are essential for its potent antimalarial activity.

Entities:  

Keywords:  Natural products; PKS-NRPS; biological activity; biosynthesis; malaria

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Year:  2020        PMID： 32043422     DOI： 10.1080/09168451.2020.1725419

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  3 in total

1.  Fusarins G-L with Inhibition of NO in RAW264.7 from Marine-Derived Fungus Fusarium solani 7227.

Authors:  Guangyuan Luo; Li Zheng; Qilin Wu; Senhua Chen; Jing Li; Lan Liu
Journal:  Mar Drugs       Date:  2021-05-25       Impact factor: 5.118

2.  Genome and Metabolome MS-Based Mining of a Marine Strain of Aspergillus affinis.

Authors:  Micael F M Gonçalves; Sandra Hilário; Marta Tacão; Yves Van de Peer; Artur Alves; Ana C Esteves
Journal:  J Fungi (Basel)       Date:  2021-12-18

3.  Fusaripyridines A and B; Highly Oxygenated Antimicrobial Alkaloid Dimers Featuring an Unprecedented 1,4-Bis(2-hydroxy-1,2-dihydropyridin-2-yl)butane-2,3-dione Core from the Marine Fungus Fusarium sp. LY019.

Authors:  Lamiaa A Shaala; Torki Alzughaibi; Grégory Genta-Jouve; Diaa T A Youssef
Journal:  Mar Drugs       Date:  2021-09-06       Impact factor: 5.118
  3 in total

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