Adi Rosenthal1, Monet S Meyer1, Danessa Mayo1, Laura M Tully1, Pooja Patel1,2, Stefania Ashby1,3, Madison Titone1,4, Cameron S Carter1,5, Tara A Niendam1. 1. Department of Psychiatry & Behavioral Sciences, University of California-Davis, Sacramento, California. 2. Department of Psychology, University of California-Los Angeles, Westwood, California. 3. Department of Psychology, University of Oregon, Eugene, Oregon. 4. Department of Psychology, Temple University, Philadelphia, Pennsylvania. 5. Center for Neuroscience, University of California-Davis, Davis, California.
Abstract
AIM: The trauma-psychosis cycle proposes an interactive relationship between impaired developmental and cognitive trajectory, childhood trauma exposure, and increased risk for psychosis. This study explored how childhood trauma (CT) and atypical development (AD) impact clinical course in an early psychosis cohort. METHODS: A retrospective chart review of behavioural and clinical research data was conducted with individuals ages 12 to 40 (N = 508; 72.4% males) evaluated by an early psychosis program. RESULTS: CT exposure was associated with earlier onset of full threshold psychosis, more hospitalizations, higher ratings of negative symptoms, and increased likelihood of engaging in suicidal behaviour. AD alone was associated with earlier onset of psychosis symptoms, higher ratings of negative symptoms and greater likelihood of engaging in non-suicidal self-injury. The combination of CT and AD was associated with the earliest symptom onset and poorest psychosocial functioning. CONCLUSIONS: The findings contribute to our understanding of heterogeneity in the early psychosis population and highlight the specific risk factors that could be targets in treatment.
AIM: The trauma-psychosis cycle proposes an interactive relationship between impaired developmental and cognitive trajectory, childhood trauma exposure, and increased risk for psychosis. This study explored how childhood trauma (CT) and atypical development (AD) impact clinical course in an early psychosis cohort. METHODS: A retrospective chart review of behavioural and clinical research data was conducted with individuals ages 12 to 40 (N = 508; 72.4% males) evaluated by an early psychosis program. RESULTS: CT exposure was associated with earlier onset of full threshold psychosis, more hospitalizations, higher ratings of negative symptoms, and increased likelihood of engaging in suicidal behaviour. AD alone was associated with earlier onset of psychosis symptoms, higher ratings of negative symptoms and greater likelihood of engaging in non-suicidal self-injury. The combination of CT and AD was associated with the earliest symptom onset and poorest psychosocial functioning. CONCLUSIONS: The findings contribute to our understanding of heterogeneity in the early psychosis population and highlight the specific risk factors that could be targets in treatment.
Authors: Mary Cannon; Avshalom Caspi; Terrie E Moffitt; HonaLee Harrington; Alan Taylor; Robin M Murray; Richie Poulton Journal: Arch Gen Psychiatry Date: 2002-05
Authors: Deanna M Barch; Matthew D Albaugh; Shelli Avenevoli; Linda Chang; Duncan B Clark; Meyer D Glantz; James J Hudziak; Terry L Jernigan; Susan F Tapert; Debbie Yurgelun-Todd; Nelly Alia-Klein; Alexandra S Potter; Martin P Paulus; Devin Prouty; Robert A Zucker; Kenneth J Sher Journal: Dev Cogn Neurosci Date: 2017-11-03 Impact factor: 6.464