Yue Wang1,2,3, Jingjing Xiao1, Yu Luo4, Shaoshi Wang1, Huazheng Liang1,3, Lingjing Jin2. 1. Department of Neurology, Shanghai Fourth People's Hospital affiliated to Tongji University School of Medicine, Shanghai 200081, China. 2. Department of Neurology, Shanghai Tongji Hospital, Tongji University, Shanghai 200065, China. 3. Department of Neurology, Translational Research Institute of Brain and Brain-like Intelligence, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai 200081, China. 4. Department of Radiology, Shanghai Fourth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai 200081, China.
Abstract
BACKGROUND: To assess the prevalence and potential predictors of MR diffusion and perfusion abnormalities in a Chinese population with hemispheric transient ischemic attacks (TIA). METHODS: Patients with temporary (<24 hours) focal cerebral dysfunction of probable vascular origin were considered to be potential candidates for this study in the emergency room. Those who were admitted to the stroke center of Shanghai Fourth People's Hospital affiliated to Tongji University between January 2015 and December 2018 were recruited to the present study. MRI, including both diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI), was performed within 7 days after the last symptom attack. Time to maximum of the residue function (Tmax) maps were auto-evaluated using the RAPID software to determine hypoperfusion. Multivariate analysis was used to assess the correlation of MR findings with clinical variables, medical history, cardio-metabolic characteristics, and the ABCD2 scores (age, blood pressure, clinical features, symptom duration and diabetes). RESULTS: Sixty-six out of 207 patients met the inclusion criteria. Baseline MRI showed DWI lesions in 20 patients (30.3%). The prevalence of MR perfusion Tmax >4 s >0 mL and ≥10 mL were 77.3% (51/66) and 50% (33/66), respectively. Male patients tended to develop DWI lesions after a TIA. Limb weakness was an independent factor associated with MR perfusion abnormalities (Tmax >4 s ≥10 mL) in this Chinese population (adjusted OR =7.41, 95% CI: 1.57-34.89, P=0.011). CONCLUSIONS: Our results suggest that limb weakness is a strong predictor of perfusion abnormalities calculated by RAPID on Tmax maps of hemispheric TIA patients without DWI positive findings. Male patients are more likely to develop cerebral infarction. 2019 Annals of Translational Medicine. All rights reserved.
BACKGROUND: To assess the prevalence and potential predictors of MR diffusion and perfusion abnormalities in a Chinese population with hemispheric transient ischemic attacks (TIA). METHODS: Patients with temporary (<24 hours) focal cerebral dysfunction of probable vascular origin were considered to be potential candidates for this study in the emergency room. Those who were admitted to the stroke center of Shanghai Fourth People's Hospital affiliated to Tongji University between January 2015 and December 2018 were recruited to the present study. MRI, including both diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI), was performed within 7 days after the last symptom attack. Time to maximum of the residue function (Tmax) maps were auto-evaluated using the RAPID software to determine hypoperfusion. Multivariate analysis was used to assess the correlation of MR findings with clinical variables, medical history, cardio-metabolic characteristics, and the ABCD2 scores (age, blood pressure, clinical features, symptom duration and diabetes). RESULTS: Sixty-six out of 207 patients met the inclusion criteria. Baseline MRI showed DWI lesions in 20 patients (30.3%). The prevalence of MR perfusion Tmax >4 s >0 mL and ≥10 mL were 77.3% (51/66) and 50% (33/66), respectively. Male patients tended to develop DWI lesions after a TIA. Limb weakness was an independent factor associated with MR perfusion abnormalities (Tmax >4 s ≥10 mL) in this Chinese population (adjusted OR =7.41, 95% CI: 1.57-34.89, P=0.011). CONCLUSIONS: Our results suggest that limb weakness is a strong predictor of perfusion abnormalities calculated by RAPID on Tmax maps of hemispheric TIA patients without DWI positive findings. Male patients are more likely to develop cerebral infarction. 2019 Annals of Translational Medicine. All rights reserved.
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