Yan-Li Wang1, Xin-Yi Leng2, Yi Dong3, Xiao-He Hou1, Lin Tong4, Ya-Hui Ma1, Wei Xu1, Mei Cui3, Qiang Dong3, Lan Tan1, Jin-Tai Yu3. 1. Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao 266071, China. 2. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. 3. Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China. 4. Department of Neurology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai 264100, China.
Abstract
BACKGROUND: Intracranial atherosclerotic stenosis (ICAS) is the most common cause of stroke, but the relationship of ICAS with fasting blood glucose (FBG) and glycated hemoglobin A1c (HbA1c) is unclear. This study aimed to investigate the effects of increased FBG and HbA1c concentration on ICAS. METHODS: A total of 4,012 patients aged over 40 years who underwent cerebral magnetic resonance angiography (MRA) were enrolled in this study, including 1,434 non-stroke controls and 2,578 patients with ischemic stroke. Participants were classified into four groups according to stroke and ICAS status. ICAS was defined as the presence of ≥50% stenosis in any intracranial artery. Multivariate regression analysis was used to evaluate the associations of FBG and HbA1c with ICAS. RESULTS: Levels of fasting glucose and HbA1c in patients with ICAS were significantly higher than those in patients without ICAS among both stroke and non-stroke groups. Multivariate regression analysis showed that elevated levels of fasting glucose (OR 1.14, 95% CI, 1.11-1.18, P<0.001) and HbA1c (OR 1.22, 95% CI, 1.16-1.28, P<0.001) were independent risk factors for ICAS. In addition, patients with the DM (FBG ≥7.0 mmol/L) were at the high risk of ICAS in both non-stroke (OR 2.90, 95% CI, 2.11-3.99, P<0.001) and stroke (OR 1.99, 95% CI, 1.67-2.39, P<0.001) groups. Besides, subjects with the high risk of ICAS were found in the fourth HbA1c quartile in both non-stroke (OR 3.50, 95% CI, 2.23-5.61, P<0.001) and stroke (OR 1.98, 95% CI, 1.50-2.63, P<0.001) groups. CONCLUSIONS: The results suggest that elevated fasting glucose and HbA1c levels are associated with high risk for ICAS. 2019 Annals of Translational Medicine. All rights reserved.
BACKGROUND: Intracranial atherosclerotic stenosis (ICAS) is the most common cause of stroke, but the relationship of ICAS with fasting blood glucose (FBG) and glycated hemoglobin A1c (HbA1c) is unclear. This study aimed to investigate the effects of increased FBG and HbA1c concentration on ICAS. METHODS: A total of 4,012 patients aged over 40 years who underwent cerebral magnetic resonance angiography (MRA) were enrolled in this study, including 1,434 non-stroke controls and 2,578 patients with ischemic stroke. Participants were classified into four groups according to stroke and ICAS status. ICAS was defined as the presence of ≥50% stenosis in any intracranial artery. Multivariate regression analysis was used to evaluate the associations of FBG and HbA1c with ICAS. RESULTS: Levels of fasting glucose and HbA1c in patients with ICAS were significantly higher than those in patients without ICAS among both stroke and non-stroke groups. Multivariate regression analysis showed that elevated levels of fasting glucose (OR 1.14, 95% CI, 1.11-1.18, P<0.001) and HbA1c (OR 1.22, 95% CI, 1.16-1.28, P<0.001) were independent risk factors for ICAS. In addition, patients with the DM (FBG ≥7.0 mmol/L) were at the high risk of ICAS in both non-stroke (OR 2.90, 95% CI, 2.11-3.99, P<0.001) and stroke (OR 1.99, 95% CI, 1.67-2.39, P<0.001) groups. Besides, subjects with the high risk of ICAS were found in the fourth HbA1c quartile in both non-stroke (OR 3.50, 95% CI, 2.23-5.61, P<0.001) and stroke (OR 1.98, 95% CI, 1.50-2.63, P<0.001) groups. CONCLUSIONS: The results suggest that elevated fasting glucose and HbA1c levels are associated with high risk for ICAS. 2019 Annals of Translational Medicine. All rights reserved.
Authors: Jin Zhang; Yan Li; Yan Wang; Wenquan Niu; Yi Zhang; Pingjin Gao; Liyun Zhang; Huawei Lin; Kemin Chen; Dingliang Zhu Journal: Am J Hypertens Date: 2010-12-16 Impact factor: 2.689
Authors: Qiao Wang; Yuanyuan Zhao; Xiang Wang; Xiaokang Ji; Shaowei Sang; Sai Shao; Xiaotong Ma; Guangbin Wang; Ming Lv; Fuzhong Xue; Yifeng Du; Qinjian Sun Journal: BMJ Open Diabetes Res Care Date: 2020-12