Literature DB >> 32042416

Paternal age is affected by genetic abnormalities, perinatal complications and mental health of the offspring.

Dominika Janeczko1, Magdalena Hołowczuk1, Anna Orzeł1, Barbara Klatka1, Andrzej Semczuk1.   

Abstract

Infertility and fecundity problems concern 10-18% of partners in their reproductive years compromising around one million females and males in Poland. Research and analysis of factors that affect male fertility are limited, especially, regarding the age of the father and determining the age at which quality of semen decreases. Age of the father has greater impact than maternal age, on cases of sporadic autosomal dominant congenital diseases such as Apert, Crouzon, Pfeiffer, Noonan and Costello syndromes, multiple endocrine neoplasia (types 2A and 2B) and achondroplasia. However, there are only a few reports taking paternal advanced age into consideration for pre-mature birth, low Apgar scores or admission to a neonatal intensive care department. Paternal age increases the frequency of congenital diseases such as heart malformations as well as oral, palate and lip cleft. Moreover, mental disorders (autism, schizophrenia, bipolar disorder, low IQ level as well as ADHD) also occur more frequently in advanced father's age. Advanced paternal age is defined differently in every research. It depends on disorders in offspring we are talking about. Paternal age has an impact on child's health and development and it is as significant as maternal age, when it comes to reproductive matters.
Copyright © 2019, Spandidos Publications.

Entities:  

Keywords:  autism; congenital abnormalities; infertility; male; mental disorders; paternal age

Year:  2019        PMID: 32042416      PMCID: PMC7006092          DOI: 10.3892/br.2019.1266

Source DB:  PubMed          Journal:  Biomed Rep        ISSN: 2049-9434


  59 in total

1.  Advanced paternal age and stillbirth rate: a nationwide register-based cohort study of 944,031 pregnancies in Denmark.

Authors:  Stine Kjaer Urhoj; Per Kragh Andersen; Laust Hvas Mortensen; George Davey Smith; Anne-Marie Nybo Andersen
Journal:  Eur J Epidemiol       Date:  2017-03-07       Impact factor: 8.082

2.  Advancing paternal age and risk of autism: new evidence from a population-based study and a meta-analysis of epidemiological studies.

Authors:  C M Hultman; S Sandin; S Z Levine; P Lichtenstein; A Reichenberg
Journal:  Mol Psychiatry       Date:  2010-11-30       Impact factor: 15.992

3.  Advancing paternal age and autism.

Authors:  Abraham Reichenberg; Raz Gross; Mark Weiser; Michealine Bresnahan; Jeremy Silverman; Susan Harlap; Jonathan Rabinowitz; Cory Shulman; Dolores Malaspina; Gad Lubin; Haim Y Knobler; Michael Davidson; Ezra Susser
Journal:  Arch Gen Psychiatry       Date:  2006-09

4.  Parental age and the risk of isolated cleft lip: a registry-based study.

Authors:  Erik Berg; Rolv T Lie; Åse Sivertsen; Øystein A Haaland
Journal:  Ann Epidemiol       Date:  2015-05-14       Impact factor: 3.797

Review 5.  Long-term effects of delayed parenthood.

Authors:  J J Tarín; J Brines; A Cano
Journal:  Hum Reprod       Date:  1998-09       Impact factor: 6.918

Review 6.  Infertility in the light of new scientific reports - focus on male factor.

Authors:  Piotr Szkodziak; Slawomir Wozniak; Piotr Czuczwar; Ewa Wozniakowska; Paweł Milart; Artur Mroczkowski; Tomasz Paszkowski
Journal:  Ann Agric Environ Med       Date:  2016-06-02       Impact factor: 1.447

Review 7.  Paternal age and mental health of offspring.

Authors:  Dolores Malaspina; Caitlin Gilman; Thorsten Manfred Kranz
Journal:  Fertil Steril       Date:  2015-05-05       Impact factor: 7.329

8.  Patterns and rates of exonic de novo mutations in autism spectrum disorders.

Authors:  Benjamin M Neale; Yan Kou; Li Liu; Avi Ma'ayan; Kaitlin E Samocha; Aniko Sabo; Chiao-Feng Lin; Christine Stevens; Li-San Wang; Vladimir Makarov; Paz Polak; Seungtai Yoon; Jared Maguire; Emily L Crawford; Nicholas G Campbell; Evan T Geller; Otto Valladares; Chad Schafer; Han Liu; Tuo Zhao; Guiqing Cai; Jayon Lihm; Ruth Dannenfelser; Omar Jabado; Zuleyma Peralta; Uma Nagaswamy; Donna Muzny; Jeffrey G Reid; Irene Newsham; Yuanqing Wu; Lora Lewis; Yi Han; Benjamin F Voight; Elaine Lim; Elizabeth Rossin; Andrew Kirby; Jason Flannick; Menachem Fromer; Khalid Shakir; Tim Fennell; Kiran Garimella; Eric Banks; Ryan Poplin; Stacey Gabriel; Mark DePristo; Jack R Wimbish; Braden E Boone; Shawn E Levy; Catalina Betancur; Shamil Sunyaev; Eric Boerwinkle; Joseph D Buxbaum; Edwin H Cook; Bernie Devlin; Richard A Gibbs; Kathryn Roeder; Gerard D Schellenberg; James S Sutcliffe; Mark J Daly
Journal:  Nature       Date:  2012-04-04       Impact factor: 49.962

9.  Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations.

Authors:  Brian J O'Roak; Laura Vives; Santhosh Girirajan; Emre Karakoc; Niklas Krumm; Bradley P Coe; Roie Levy; Arthur Ko; Choli Lee; Joshua D Smith; Emily H Turner; Ian B Stanaway; Benjamin Vernot; Maika Malig; Carl Baker; Beau Reilly; Joshua M Akey; Elhanan Borenstein; Mark J Rieder; Deborah A Nickerson; Raphael Bernier; Jay Shendure; Evan E Eichler
Journal:  Nature       Date:  2012-04-04       Impact factor: 49.962

10.  Advanced paternal age is associated with impaired neurocognitive outcomes during infancy and childhood.

Authors:  Sukanta Saha; Adrian G Barnett; Claire Foldi; Thomas H Burne; Darryl W Eyles; Stephen L Buka; John J McGrath
Journal:  PLoS Med       Date:  2009-03-10       Impact factor: 11.069

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  2 in total

Review 1.  Advanced Paternal Age and Future Generations.

Authors:  Peter T K Chan; Bernard Robaire
Journal:  Front Endocrinol (Lausanne)       Date:  2022-06-09       Impact factor: 6.055

2.  Advanced paternal age and risk of cancer in offspring.

Authors:  Yangyang Sun; Xu Li; Wei Jiang; Yuanming Fan; Qiong Ouyang; Wei Shao; Raphael N Alolga; Yuqiu Ge; Gaoxiang Ma
Journal:  Aging (Albany NY)       Date:  2020-12-19       Impact factor: 5.682

  2 in total

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