Literature DB >> 32042174

Myelin degeneration and diminished myelin renewal contribute to age-related deficits in memory.

Fei Wang1, Shu-Yu Ren1, Jing-Fei Chen1, Kun Liu1, Rui-Xue Li1, Zhi-Fang Li1,2, Bo Hu3, Jian-Qin Niu1, Lan Xiao1, Jonah R Chan4, Feng Mei5.   

Abstract

Cognitive decline remains an unaddressed problem for the elderly. We show that myelination is highly active in young mice and greatly inhibited in aged mice, coinciding with spatial memory deficits. Inhibiting myelination by deletion of Olig2 in oligodendrocyte precursor cells impairs spatial memory in young mice, while enhancing myelination by deleting the muscarinic acetylcholine receptor 1 in oligodendrocyte precursor cells, or promoting oligodendroglial differentiation and myelination via clemastine treatment, rescues spatial memory decline during aging.

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Year:  2020        PMID： 32042174      PMCID： PMC7306053          DOI： 10.1038/s41593-020-0588-8

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  62 in total

1.  The Journal of Neuroscience's 40th Anniversary: Looking Back, Looking Forward.

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Review 2.  [Mechanisms underlying remyelination with special focus on demyelination models of multiple sclerosis].

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3.  Can oligodendrocyte precursor cells be a therapeutic target for mitigating cognitive decline in cerebrovascular disease?

Authors:  Ken Arai
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Review 4.  Myelin plasticity: sculpting circuits in learning and memory.

Authors:  Wendy Xin; Jonah R Chan
Journal:  Nat Rev Neurosci       Date:  2020-10-12       Impact factor: 34.870

Review 5.  Building a (w)rapport between neurons and oligodendroglia: Reciprocal interactions underlying adaptive myelination.

Authors:  Sarah E Pease-Raissi; Jonah R Chan
Journal:  Neuron       Date:  2021-02-22       Impact factor: 17.173

6.  miR-142-3p regulates cortical oligodendrocyte gene co-expression networks associated with tauopathy.

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Journal:  Hum Mol Genet       Date:  2021-03-25       Impact factor: 6.150

Review 7.  The memory orchestra: the role of astrocytes and oligodendrocytes in parallel to neurons.

Authors:  Adi Kol; Inbal Goshen
Journal:  Curr Opin Neurobiol       Date:  2020-11-28       Impact factor: 6.627

Review 8.  Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders.

Authors:  Jan Spaas; Lieve van Veggel; Melissa Schepers; Assia Tiane; Jack van Horssen; David M Wilson; Pablo R Moya; Elisabeth Piccart; Niels Hellings; Bert O Eijnde; Wim Derave; Rudy Schreiber; Tim Vanmierlo
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Review 9.  Glial restricted precursor cells in central nervous system disorders: Current applications and future perspectives.

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