Literature DB >> 32040324

Ikoamide, an Antimalarial Lipopeptide from an Okeania sp. Marine Cyanobacterium.

Keitaro Iwasaki1, Arihiro Iwasaki1, Shimpei Sumimoto1, Teruhiko Matsubara2, Toshinori Sato2, Tomoyoshi Nozaki3, Yumiko Saito-Nakano4, Kiyotake Suenaga1.   

Abstract

An antimalarial lipopeptide, ikoamide, was isolated from an Okeania sp. marine cyanobacterium. Its gross structure was established by spectroscopic analyses, and the absolute configuration was clarified based on a combination of chiral-phase HPLC analyses, spectroscopic analyses, and derivatization reactions. Ikoamide showed strong antimalarial activity with an IC50 value of 0.14 μM without cytotoxicity against human cancer cell lines at 10 μM.

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Year:  2020        PMID： 32040324     DOI： 10.1021/acs.jnatprod.9b01147

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  3 in total

Review 1.  An overview of chiral separations of pharmaceutically active substances by HPLC (2018-2020).

Authors:  Sofiya Grybinik; Zuzana Bosakova
Journal:  Monatsh Chem       Date:  2021-08-24       Impact factor: 1.451

2.  Bioactivities of Lyngbyabellins from Cyanobacteria of Moorea and Okeania Genera.

Authors:  Imam Fathoni; Julie G Petitbois; Walied M Alarif; Ahmed Abdel-Lateff; Sultan S Al-Lihaibi; Erina Yoshimura; Yasuyuki Nogata; Charles S Vairappan; Eti Nurwening Sholikhah; Tatsufumi Okino
Journal:  Molecules       Date:  2020-09-01       Impact factor: 4.411

Review 3.  Potentials of marine natural products against malaria, leishmaniasis, and trypanosomiasis parasites: a review of recent articles.

Authors:  Justus Amuche Nweze; Florence N Mbaoji; Yan-Ming Li; Li-Yan Yang; Shu-Shi Huang; Vincent N Chigor; Emmanuel A Eze; Li-Xia Pan; Ting Zhang; Deng-Feng Yang
Journal:  Infect Dis Poverty       Date:  2021-01-22       Impact factor: 4.520
  3 in total

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