Literature DB >> 32039707

Correction to: Association of CMV genomic mutations with symptomatic infection and hearing loss in congenital CMV infection.

G Clement Dobbins1, Amit Patki2, Dongquan Chen3,4, Hemant K Tiwari2, Curtis Hendrickson5, William J Britt6,3, Karen Fowler6, Jake Y Chen3, Suresh B Boppana6,5, Shannon A Ross7,8.   

Abstract

After publication of the original article [1], we were notified that Fig. 3 has "Fig. 1" posted on the top of it and Figs. 4 and 5 have "Genomic Position" in a different spot.

Entities:  

Year:  2020        PMID: 32039707      PMCID: PMC7008528          DOI: 10.1186/s12879-020-4766-9

Source DB:  PubMed          Journal:  BMC Infect Dis        ISSN: 1471-2334            Impact factor:   3.090


Correction to: BMC Infect Dis https://doi.org/10.1186/s12879-019-4681-0 After publication of the original article [1], we were notified that Fig. 3 has “Fig. 1” posted on the top of it and Figs. 4 and 5 have “Genomic Position” in a different spot.
Fig. 3

CMV variants in symptomatic and asymptomatic children. a Variant density of CMV genomes isolated from newborns (17 asymptomatic, 13 symptomatic) calculated in 1000 bp windows with Merlin as the reference strain. b Variants more frequent in symptomatic infection (Fisher’s exact test p < 0.05) are plotted with the genome position. The coding regions with the highest number of such variants are listed in their relative genomic position. c UL55 NSVs in relation to known antigenic domains (AD). Top panel shows the amino acid sequence of CMV strain Merlin. Bottom panel shows where NSVs (indicated by arrows below the reference strain) are more likely seen in infants with symptomatic congenital CMV in relation to antigenic domains

Fig. 4

CMV variation from children with normal hearing and SNHL. Variant density of CMV genomes isolated from 17 children with normal hearing and 13 children with SNHL calculated in a 1000 bp sliding window with Merlin as the reference strain. Variants more frequent in viruses from children with SNHL (Fisher’s exact test p < 0.05) are plotted with the genome position. The coding regions with the highest number of variants are listed with the genomic position

Fig. 5

CMV variants from asymptomatic children with normal hearing and SNHL. Variant density of CMV genomes isolated from 11 asymptomatic newborns with normal hearing and 6 asymptomatic newborns that developed SNHL calculated in a 1000 bp sliding window with Merlin as the reference strain. Regions with variants more frequent in viruses from children with asymptomatic infection and SNHL (Fisher’s exact test p < 0.05) are plotted with the genome position

Below you can find the correct figures: CMV variants in symptomatic and asymptomatic children. a Variant density of CMV genomes isolated from newborns (17 asymptomatic, 13 symptomatic) calculated in 1000 bp windows with Merlin as the reference strain. b Variants more frequent in symptomatic infection (Fisher’s exact test p < 0.05) are plotted with the genome position. The coding regions with the highest number of such variants are listed in their relative genomic position. c UL55 NSVs in relation to known antigenic domains (AD). Top panel shows the amino acid sequence of CMV strain Merlin. Bottom panel shows where NSVs (indicated by arrows below the reference strain) are more likely seen in infants with symptomatic congenital CMV in relation to antigenic domains CMV variation from children with normal hearing and SNHL. Variant density of CMV genomes isolated from 17 children with normal hearing and 13 children with SNHL calculated in a 1000 bp sliding window with Merlin as the reference strain. Variants more frequent in viruses from children with SNHL (Fisher’s exact test p < 0.05) are plotted with the genome position. The coding regions with the highest number of variants are listed with the genomic position CMV variants from asymptomatic children with normal hearing and SNHL. Variant density of CMV genomes isolated from 11 asymptomatic newborns with normal hearing and 6 asymptomatic newborns that developed SNHL calculated in a 1000 bp sliding window with Merlin as the reference strain. Regions with variants more frequent in viruses from children with asymptomatic infection and SNHL (Fisher’s exact test p < 0.05) are plotted with the genome position The original article has been corrected.
  1 in total

1.  Association of CMV genomic mutations with symptomatic infection and hearing loss in congenital CMV infection.

Authors:  G Clement Dobbins; Amit Patki; Dongquan Chen; Hemant K Tiwari; Curtis Hendrickson; William J Britt; Karen Fowler; Jake Y Chen; Suresh B Boppana; Shannon A Ross
Journal:  BMC Infect Dis       Date:  2019-12-10       Impact factor: 3.090

  1 in total

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