| Literature DB >> 32038795 |
Sudeep R Bista1, Sang Kyu Lee2, Dinesh Thapa1, Mi Jeong Kang1, Young Min Seo1, Ju Hyun Kim1, Dong Hyeon Kim1, Yurngdong Jahng1, Jung Ae Kim1, Tae Cheon Jeong1.
Abstract
It has been reported that hepatic microsomal cytochrome P450 (CYP) 2E1 is responsible for the metabolism of chlorzoxazone (CZX) to 6-hydroxychlorzoxazone. The present study was undertaken to assess the possible interaction of rutaecarpine, an alkaloid originally isolated from the unripe fruit of Evodia rutaecarpa, with CZX. Male Spraque-Dawley rats were administered with 80 mg/kg/day of oral rutaecarpine for three consecutive days. Twenty four hr after the pre-treatment with rutaecarpine, the rats were treated with 20 mg/kg of intravenous CZX Rat hepatic microsomes isolated from rutaecarpine-treated rats showed greater (50% increase) activity of p-nitrophenol hydroxylase (a marker of CYP2E1) when compared with the control rats. Compared with control rats, the AUC of CZX was significantly smaller (84% decrease) possibly due to significantly faster CL (646% increase) in rats pretreated with rutaecarpine. This could be, at least partially, due to induction of CYP2E1 by rutaecarpine. © Korean Society of Toxicology 2008.Entities:
Keywords: CYP2E1; Chlorzoxazone; In vivo; Interaction; Pharmacokinetics; Rutaecarpine
Year: 2008 PMID： 32038795 PMCID： PMC7006287 DOI： 10.5487/TR.2008.24.3.195
Source DB: PubMed Journal: Toxicol Res ISSN： 1976-8257