Nils Berginström1,2, Peter Nordström1, Lars Nyberg3,4,5, Anna Nordström6,7. 1. Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden. 2. Department of Psychology, Umeå University, Umeå, Sweden. 3. Umeå Center for Functional Brain Imaging (UFBI), Umeå University, Umeå, Sweden. 4. Physiology Section, Department of Integrative Medical Biology, Umeå University, Umeå, Sweden. 5. Department of Radiation Sciences, Umeå University, Umeå, Sweden. 6. Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, Umeå University, Umeå, Sweden. 7. School of Sport Sciences, The Arctic University of Norway, Tromsø, Norway.
Abstract
Objective: To examine the prevalence of white matter hyperintensities (WMHs) in patients with traumatic brain injury (TBI) as compared to healthy controls, and to investigate whether there is an association between WMH lesion burden and performance on neuropsychological tests in patients with TBI. Methods: A total of 59 patients with TBI and 27 age- and gender-matched healthy controls underwent thorough neuropsychological testing and magnetic resonance imaging. The quantification of WMH lesions was performed using the fully automated Lesion Segmentation Tool. Results: WMH lesions were more common in patients with TBI than in healthy controls (p = .032), and increased with higher TBI severity (p = .025). Linear regressions showed that WMH lesions in patients with TBI were not related to performance on any neuropsychological tests (p > .05 for all). However, a negative relationship between number of WMH lesions in patients with TBI and self-assessed fatigue was found (r = - 0.33, p = .026). Conclusion: WMH lesions are more common in patients with TBI than in healthy controls, and WMH lesions burden increases with TBI severity. These lesions could not explain decreased cognitive functioning in patients with TBI but did relate to decreased self-assessment of fatigue after TBI.
Objective: To examine the prevalence of white matter hyperintensities (WMHs) in patients with traumatic brain injury (TBI) as compared to healthy controls, and to investigate whether there is an association between WMH lesion burden and performance on neuropsychological tests in patients with TBI. Methods: A total of 59 patients with TBI and 27 age- and gender-matched healthy controls underwent thorough neuropsychological testing and magnetic resonance imaging. The quantification of WMH lesions was performed using the fully automated Lesion Segmentation Tool. Results: WMH lesions were more common in patients with TBI than in healthy controls (p = .032), and increased with higher TBI severity (p = .025). Linear regressions showed that WMH lesions in patients with TBI were not related to performance on any neuropsychological tests (p > .05 for all). However, a negative relationship between number of WMH lesions in patients with TBI and self-assessed fatigue was found (r = - 0.33, p = .026). Conclusion: WMH lesions are more common in patients with TBI than in healthy controls, and WMH lesions burden increases with TBI severity. These lesions could not explain decreased cognitive functioning in patients with TBI but did relate to decreased self-assessment of fatigue after TBI.
Entities:
Keywords:
Traumatic Brain Injury; fatigue; magnetic Resonance Imaging; neuropsychology; white matter hyperintensities
Authors: Elisabeth A Wilde; Ina-Beate Wanner; Kimbra Kenney; Jessica Gill; James R Stone; Seth Disner; Caroline Schnakers; Retsina Meyer; Eric M Prager; Magali Haas; Andreas Jeromin Journal: J Neurotrauma Date: 2022-02-14 Impact factor: 5.269