Nadia Rashid1, Aruna Nigam2, Sana Kauser1, Prem Prakash3, S K Jain4, Saima Wajid1. 1. Department of Biotechnology, School of Chemical and Life Sciences, Jamia Hamdard, New Delhi, India. 2. Department of Gynaecology and Obstetrics, Hamdard Institute of Medical Sciences and Research, New Delhi, India. 3. Jamia Hamdard Institute of Molecular Medicine (JHIMM), Jamia Hamdard, New Delhi, India. 4. Department of Biochemistry, Hamdard Institute of Medical Sciences and Research, New Delhi, India.
Abstract
BACKGROUND: Polycystic ovarian syndrome has emerged as a cardiometabolic disorder and aim of this study was to evaluate various surrogate indices and their diagnostic potential to determine the most convenient and cost-effective marker of IR, CVD, and MetS in these women. MATERIALS AND METHODS: Ninety-five PCOS women and 45 age matched healthy women were enrolled. Measures included anthropometric and biochemical parameters, BMI, WHR, WHtR, BAI, VAI, LAP, HOMA-IR, and lipid profile. RESULTS: LAP has highest AUC value 0.781 with cut-off value = 39.73 (sensitivity = 75% and specificity = 79.5%) for predicting IR and AUC value 0.83 with cut-off value = 35.63 (sensitivity = 94.4% and specificity = 77.3%) for predicting MetS in women with PCOS. LAP had statistically strong positive correlation with WC, BMI, WHR, fasting glucose, fasting insulin, HOMA-IR, TC, TG, and SBP. CONCLUSIONS: LAP is a powerful and reliable marker for assessment of IR, CVD, and MetS risk in young Indian women with PCOS.
BACKGROUND: Polycystic ovarian syndrome has emerged as a cardiometabolic disorder and aim of this study was to evaluate various surrogate indices and their diagnostic potential to determine the most convenient and cost-effective marker of IR, CVD, and MetS in these women. MATERIALS AND METHODS: Ninety-five PCOS women and 45 age matched healthy women were enrolled. Measures included anthropometric and biochemical parameters, BMI, WHR, WHtR, BAI, VAI, LAP, HOMA-IR, and lipid profile. RESULTS: LAP has highest AUC value 0.781 with cut-off value = 39.73 (sensitivity = 75% and specificity = 79.5%) for predicting IR and AUC value 0.83 with cut-off value = 35.63 (sensitivity = 94.4% and specificity = 77.3%) for predicting MetS in women with PCOS. LAP had statistically strong positive correlation with WC, BMI, WHR, fasting glucose, fasting insulin, HOMA-IR, TC, TG, and SBP. CONCLUSIONS: LAP is a powerful and reliable marker for assessment of IR, CVD, and MetS risk in young Indian women with PCOS.
Authors: Małgorzata Kałużna; Magdalena Czlapka-Matyasik; Pola Kompf; Jerzy Moczko; Katarzyna Wachowiak-Ochmańska; Adam Janicki; Karolina Samarzewska; Marek Ruchała; Katarzyna Ziemnicka Journal: Ther Adv Endocrinol Metab Date: 2022-01-10 Impact factor: 3.565