Scott Barbuto1, Dario Martelli2, Isarime Babajide Omofuma2, Nancy Lee1, Sheng-Han Kuo3, Sunil Agrawal2, Seonjoo Lee4, Michael O'Dell5, Joel Stein5,6,7. 1. Department of Physical Medicine and Rehabilitation, Vagelos College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA. 2. Department of Mechanical Engineering, Columbia University, New York, NY, USA. 3. Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA. 4. Department of Biostatistics, Vagelos College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA. 5. Department of Rehabilitation Medicine, Weill Cornell Medical College, Cornell University, New York, NY, USA. 6. Department of Rehabilitation and Regenerative Medicine, Vagelos College of Physicians and Surgeons, Columbia University. 7. NewYork-Presbyterian Hospital, New York, NY, USA.
Abstract
OBJECTIVES: To investigate whether people with cerebellar degeneration can perform rigorous aerobic exercise and to assess the clinical impact of training. DESIGN: Randomized single-blinded controlled, feasibility study comparing aerobic training to no training. SETTING: Home intervention, assessments conducted at an academic medical center. SUBJECTS: Twenty individuals with cerebellar degeneration caused by a range of genetic disorders. INTERVENTION: Aerobic training consisted of four weeks of stationary bicycle training, five times per week for 30-minute sessions. Intensity ranged from 65% to 80% of the participant's maximal heart rate determined during cardiopulmonary exercise testing. MAIN MEASURES: Primary outcome measure was change in the Scale for the Assessment and Rating of Ataxia scores. Recruitment rate, adherence, drop-out, and adverse events were also determined. The treatment was considered technically feasible if participants achieved target training frequency, duration, and intensity. RESULTS: The 20 participants mean age was 50 years (standard deviation 15.65 years) and average Scale for the Assessment and Rating of Ataxia score was 9.6 (standard deviation 3.13). Ten participants were randomized to aerobic training and 10 to no training. Seven participants in the aerobic group attained target training duration, frequency, and intensity. There was a mean reduction in ataxia severity of 2.1 points (standard deviation 1.26) with four weeks of aerobic training, whereas ataxia severity increased by 0.3 (standard deviation 0.62) in the control group over the same period. Walking speed, balance measures, and fitness also improved in individuals who performed aerobic exercise. CONCLUSIONS: Rigorous aerobic training is feasible in people with cerebellar degeneration. Improvements in ataxia, balance, and gait are promising.
OBJECTIVES: To investigate whether people with cerebellar degeneration can perform rigorous aerobic exercise and to assess the clinical impact of training. DESIGN: Randomized single-blinded controlled, feasibility study comparing aerobic training to no training. SETTING: Home intervention, assessments conducted at an academic medical center. SUBJECTS: Twenty individuals with cerebellar degeneration caused by a range of genetic disorders. INTERVENTION: Aerobic training consisted of four weeks of stationary bicycle training, five times per week for 30-minute sessions. Intensity ranged from 65% to 80% of the participant's maximal heart rate determined during cardiopulmonary exercise testing. MAIN MEASURES: Primary outcome measure was change in the Scale for the Assessment and Rating of Ataxia scores. Recruitment rate, adherence, drop-out, and adverse events were also determined. The treatment was considered technically feasible if participants achieved target training frequency, duration, and intensity. RESULTS: The 20 participants mean age was 50 years (standard deviation 15.65 years) and average Scale for the Assessment and Rating of Ataxia score was 9.6 (standard deviation 3.13). Ten participants were randomized to aerobic training and 10 to no training. Seven participants in the aerobic group attained target training duration, frequency, and intensity. There was a mean reduction in ataxia severity of 2.1 points (standard deviation 1.26) with four weeks of aerobic training, whereas ataxia severity increased by 0.3 (standard deviation 0.62) in the control group over the same period. Walking speed, balance measures, and fitness also improved in individuals who performed aerobic exercise. CONCLUSIONS: Rigorous aerobic training is feasible in people with cerebellar degeneration. Improvements in ataxia, balance, and gait are promising.
Authors: Ann M Swank; John Horton; Jerome L Fleg; Gregg C Fonarow; Steven Keteyian; Lee Goldberg; Gene Wolfel; Eileen M Handberg; Dan Bensimhon; Marie-Christine Illiou; Marianne Vest; Greg Ewald; Gordon Blackburn; Eric Leifer; Lawton Cooper; William E Kraus Journal: Circ Heart Fail Date: 2012-07-06 Impact factor: 8.790
Authors: Ruo-Yah Lai; Darya Tomishon; Karla P Figueroa; Stefan M Pulst; Susan Perlman; George Wilmot; Christopher M Gomez; Jeremy D Schmahmann; Henry Paulson; Vikram G Shakkottai; Sarah H Ying; Theresa Zesiewicz; Khalaf Bushara; Michael Geschwind; Guangbin Xia; S H Subramony; Tetsuo Ashizawa; Sheng-Han Kuo Journal: Cerebellum Date: 2019-06 Impact factor: 3.847
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