Literature DB >> 3203741

Isolation and characterisation of GLP-1 7-36 amide from rat intestine. Elevated levels in diabetic rats.

B Kreymann1, Y Yiangou, S Kanse, G Williams, M A Ghatei, S R Bloom.   

Abstract

Glucagon-like peptide-1 (GLP-1) was purified to homogeneity by HPLC and anion-exchange chromatography. A molecular mass of 3297.4 Da was obtained by FAB mass spectrometry which corresponded exactly to GLP-1 7-36 NH2, providing evidence that amidation occurs at an arginine residue during the post-translational processing of GLP-1. The distribution of GLP-1 7-36 NH2-like immunoreactivity (GLP-1 7-36 NH2 IR) was determined in the rat gastrointestinal tract. Highest concentrations were found in terminal ileum and colon. Streptozocin-induced diabetic rats, who showed a significant increase in food intake, had a significant increase of GLP-1 7-36 NH2 IR in the colon.

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Year:  1988        PMID： 3203741     DOI： 10.1016/0014-5793(88)81008-1

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

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Review 3.  Glucagon-like peptide-1, a new hormone of the entero-insular axis.

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Journal:  Diabetologia       Date:  1992-08       Impact factor: 10.122

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5.  Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice.

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Journal:  J Clin Res Pediatr Endocrinol       Date:  2009-02-05

8.  The short-chain fatty acid acetate reduces appetite via a central homeostatic mechanism.

Authors:  Gary Frost; Michelle L Sleeth; Meliz Sahuri-Arisoylu; Blanca Lizarbe; Sebastian Cerdan; Leigh Brody; Jelena Anastasovska; Samar Ghourab; Mohammed Hankir; Shuai Zhang; David Carling; Jonathan R Swann; Glenn Gibson; Alexander Viardot; Douglas Morrison; E Louise Thomas; Jimmy D Bell
Journal:  Nat Commun       Date:  2014-04-29       Impact factor: 14.919
  8 in total

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