Kexun Zhang1,2, Yanfeng Jiang2,3, Yingzhe Wang4, Chen Suo1,2, Kelin Xu2,5, Zhen Zhu1,2, Chengkai Zhu2,3,6, Genming Zhao1, Li Jin2,3,6, Weimin Ye2,7, Mei Cui4, Xingdong Chen2,3. 1. Department of Epidemiology, School of Public Health, and the Key Laboratory of Public Health Safety of Ministry of Education, Fudan University. 2. Fudan University Taizhou Institute of Health Sciences. 3. State Key Laboratory of Genetic Engineering, Human Phenome Institute, Fudan University. 4. Department of Neurology, Huashan Hospital, Fudan University. 5. Department of Biostatistics, and Key Laboratory of Public Health Safety, School of Public Health, Fudan University. 6. School of Life Sciences, Fudan University. 7. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet.
Abstract
AIMS: We aimed to examine the associations of four extracranial artery indicators with cerebral small vessel disease (CSVD) and its total burden. METHODS: A total of 904 individuals aged 55-65 years old were included from the Taizhou Imaging Study. CSVD markers, including lacunes (LAC), white matter hyperintensities (WMH), cerebral microbleeds (CMB), and perivascular spaces (PVS), were rated based on brain magnetic resonance imaging. We also measured extracranial artery indices, including the brachial-ankle pulse wave velocity (baPWV), the ankle-brachial index, the carotid intima-media thickness (IMT), and carotid plaque. Linear and binary logistic regressions were adopted to test the associations among these four artery indicators and each CSVD marker when appropriate. Additionally, ordinal and multinomial logistic regressions were performed to assess the relationships between artery indicators and total CSVD score (range from 0-4 points). RESULTS: A total of 443 (49.0%) participants were found to have at least one of the CSVD markers, including 172 (19.0%) with WMH, 184 (20.4%) with LAC, 147 (16.3%) with CMB, and 226 (25.0%) with PVS. Increased baPWV was significantly associated with each CSVD marker, increasing carotid IMT was associated with LAC and PVS, and the presence of carotid plaque was associated with WMH volume and PVS. Moreover, per SD increment of baPWV (odds ratio [OR]: 1.29, 95% confidence interval [CI]: 1.11-1.50) and the presence of carotid plaque (OR: 1.42, 95% CI: 1.05-1.92) were significantly associated with greater total CSVD scores. CONCLUSION: Increased baPWV and the presence of carotid plaque appear to be associated with total CSVD burden in rural regions in China.
AIMS: We aimed to examine the associations of four extracranial artery indicators with cerebral small vessel disease (CSVD) and its total burden. METHODS: A total of 904 individuals aged 55-65 years old were included from the Taizhou Imaging Study. CSVD markers, including lacunes (LAC), white matter hyperintensities (WMH), cerebral microbleeds (CMB), and perivascular spaces (PVS), were rated based on brain magnetic resonance imaging. We also measured extracranial artery indices, including the brachial-ankle pulse wave velocity (baPWV), the ankle-brachial index, the carotid intima-media thickness (IMT), and carotid plaque. Linear and binary logistic regressions were adopted to test the associations among these four artery indicators and each CSVD marker when appropriate. Additionally, ordinal and multinomial logistic regressions were performed to assess the relationships between artery indicators and total CSVD score (range from 0-4 points). RESULTS: A total of 443 (49.0%) participants were found to have at least one of the CSVD markers, including 172 (19.0%) with WMH, 184 (20.4%) with LAC, 147 (16.3%) with CMB, and 226 (25.0%) with PVS. Increased baPWV was significantly associated with each CSVD marker, increasing carotid IMT was associated with LAC and PVS, and the presence of carotid plaque was associated with WMH volume and PVS. Moreover, per SD increment of baPWV (odds ratio [OR]: 1.29, 95% confidence interval [CI]: 1.11-1.50) and the presence of carotid plaque (OR: 1.42, 95% CI: 1.05-1.92) were significantly associated with greater total CSVD scores. CONCLUSION: Increased baPWV and the presence of carotid plaque appear to be associated with total CSVD burden in rural regions in China.
Entities:
Keywords:
Arterial stiffness; Carotid atherosclerosis; Cerebral small vessel disease
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